Evidence map›Paper›PMID 39972695›Full record

ArticleJACC. Case reports2025

Female Fabry Patient With Left Ventricular Outflow Tract Obstruction.

Jiaqi Li, Meiling Chang, Zeyuan Mei, Qing Zhu, Xin Yue, Mei Zhang, Mengmeng Li, Xiaoling Liu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaqi LiState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Meiling ChangState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Zeyuan MeiState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Qing ZhuState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Xin YueState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Mei ZhangState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Mengmeng LiState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address: zpyzlmm90128@163.com.
Xiaoling LiuState Key Laboratory for Innovation and Transformation of Luobing Theory, the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address: xiaolingliusdu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac involvement in Fabry disease is usually characterized by left ventricular hypertrophy (LVH) without obstruction at rest. CASE SUMMARY: A 59-year-old female patient with progressive chest tightness misdiagnosed as having hypertrophic cardiomyopathy due to LVH with obstruction was finally diagnosed with Fabry disease. Echocardiography showed LVH with severe obstruction, "binary sign," papillary muscle hypertrophy, and depressed longitudinal strain in the basal inferolateral region. The patient felt chest tightness worsened 1 year after receiving enzyme replacement therapy. Percutaneous endocardial septal radiofrequency ablation was performed to relieve obstruction. DISCUSSION: It is rare for women with Fabry disease to present with severe symptoms, but it is possible. LVH with obstruction should not be a potential point of view to relax the vigilance of Fabry disease. Percutaneous endocardial septal radiofrequency ablation may help to relieve left ventricular outflow tract obstruction in Fabry disease. TAKE-HOME MESSAGE: Paying attention to echocardiographic characteristics is helpful for the identification of Fabry disease.

Indexed as

Fabry diseaseleft ventricular hypertrophypercutaneous endocardial septal radiofrequency ablation

Identifiers

PMID39972695
PMCPMC11861940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.