Evidence map›Paper›PMID 39972510›Full record

ArticleHarm reduction journal2025

Mechanisms of resilience and coping to intersectional HIV prevention and drug-use stigma among people who inject drugs in rural Appalachian Ohio.

Stacy Endres-Dighe, Ana D Sucaldito, Renee McDowell, Anyssa Wright, Ashleigh LoVette, William C Miller, Vivian Go, Nisha Gottfredson O'Shea, Kathryn E Lancaster

Abstract read
In one paragraph

Article in Harm reduction journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Coping strategy as a predictor of illicit drug use among persons who inject drugs.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  4. Article
  5. Article
  6. Intersectional Barriers Among PLHIV in Rural Illinois: Insights from a Pilot QCA Study.International journal of environmental research and public health · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stacy Endres-DigheDepartment of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Ave., Cunz Hall, Columbus, OH, 43210, USA. endres-dighe.1@buckeyemail.osu.edu.
Ana D SucalditoDepartment of Public Health Sciences and Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Renee McDowellDepartment of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Ave., Cunz Hall, Columbus, OH, 43210, USA.
Anyssa WrightDepartment of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Ave., Cunz Hall, Columbus, OH, 43210, USA.
Ashleigh LoVetteDepartment of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, USA.
William C MillerDepartment of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Ave., Cunz Hall, Columbus, OH, 43210, USA.
Vivian GoDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nisha Gottfredson O'SheaDivision of Biostatistics and Epidemiology, RTI International, Durham, NC, USA.
Kathryn E LancasterDepartment of Implementation Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

Implementing a Community-Based Response to the Opioid Epidemic in Rural OhioUG3DA044822 · NIDA · OHIO STATE UNIVERSITY · PI GO, VIVIAN F., MILLER, WILLIAM C · 2017 to 2018
$1.1M
The role of injection partnerships and preferences for reducing HCV risk: Giving a voice to young women in rural Appalachia.K01DA048174 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LANCASTER, KATHRYN ELIZABETH · 2019 to 2023
$841k
Measuring resilience to intersectional stigma for people who inject drugs in need of HIV preventionR21DA053708 · NIDA · OHIO STATE UNIVERSITY · PI NORRIS, ALISON H · 2021 to 2022
$446k
Examining the mediating effect of resilience on intersectional stigma and HIV prevention among people who inject drugs in rural Appalachia OhioR36DA060059 · NIDA · OHIO STATE UNIVERSITY · PI ENDRES-DIGHE, STACY M. · 2023 to 2023
$53k
NIDA NIH HHS K01 DA048174NIDA NIH HHS K01DA048174NIDA NIH HHS R21 DA053708NIDA NIH HHS R36 DA060059NIDA NIH HHS R36DA060059NIDA NIH HHS UG3 DA044822NIDA NIH HHS UG3DA044822
6 · The paper itself

Abstract

backgroundIntersectional stigma of drug-use and HIV hinders provision and utilization of HIV prevention services for people who inject drugs (PWID), particularly within rural US communities. Resilience and coping may be critical for PWID to counter pervasive stigma.

methodsBetween October 2021 and July 2022, 35 in-depth interviews were conducted in Appalachian Ohio to understand the intersection of drug-use and HIV prevention stigma and how resilience and coping processes are displayed, shared, and enacted. Interviews were audio-recorded and transcribed verbatim. Thematic analysis was conducted, guided by Harper et al.'s four key resilience processes: (a) engaging in health-promoting cognitive processes, (b) enacting in health behavioral practices, (c) exchanging social support, and (d) empowering other PWID to engage in health behavior practices.

resultsResilience processes aligned with the Harper framework with additional coping processes identified, including anticipation strategies and maladaptive coping. Empowering other PWID emerged as a prominent resiliency process, often supported by systems of support like syringe service programs (SSPs), which provided resources and helped reduce stigma. However, bidirectional social support was constrained, as PWID frequently acted as providers of resources and referrals for peers despite limited knowledge of HIV prevention strategies and feeling unsupported themselves. Anticipation strategies were employed to manage anticipated stigma, including accessing support or, conversely, avoiding healthcare and refraining from disclosing drug use. Maladaptive coping included behaviors such as social isolation and self-administered medical care, highlighting critical gaps in opportunities to foster resilience.

conclusionsFindings highlight that empowering peers and anticipation strategies can be key resilience processes, while maladaptive coping and limited bidirectional social support underscore the need for resilience-building and stigma-reduction interventions. Tailored systems of support for PWID in rural communities are critical to fostering adaptive coping and enhancing engagement with HIV prevention services.

Indexed as

Adaptation, PsychologicalHIV InfectionsResilience, PsychologicalSocial StigmaSubstance Abuse, IntravenousAdultAppalachian RegionFemaleHumansMaleMiddle AgedOhioRural PopulationSocial SupportHIVPeople who inject drugsResilienceStigma

Identifiers

PMID39972510
PMCPMC11837303

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.