ArticleAlzheimer's research & therapy2025
Social frailty and its association with cognitive trajectories in older adults: a prospective cohort study.
Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study.BMC medicine · 2026Article
- The Influence of Social and Psychological Factors on Cognition Among Liver Transplant Recipients.Progress in transplantation (Aliso Viejo, Calif.) · 2026Article
- The relationship between social frailty and self-care ability in elderly stroke patients: the mediating role of self-efficacy.Frontiers in psychology · 2026Article
- When minds and networks matter: how mental health and social capital shape social frailty in older adults.Frontiers in medicine · 2026Article
- Self-perceptions of aging and associated factors among older patients undergoing maintenance hemodialysis: a latent profile analysis.Frontiers in public health · 2026Article
- Transitions in Sarcopenia Status and Cognitive Trajectories Among Middle-Aged and Older Adults in China: Longitudinal Cohort Study.JMIR aging · 2025Article
- Assessing Social Interaction and Loneliness and Their Association With Frailty Among Older Adults With Subjective Cognitive Decline or Mild Cognitive Impairment: Ecological Momentary Assessment Approach.JMIR mHealth and uHealth · 2025Article
- Association of Social Frailty With Incident Dementia and Cognitive Decline in Middle-Aged and Older Adults: A Prospective Cohort Study.Inquiry : a journal of medical care organization, provision and financingArticle
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7 authors.
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Abstract
backgroundSocial frailty, a multidimensional construct encompassing various social behaviors, resources, and needs, significantly impacts cognitive health in older adults. Despite existing studies linking specific social factors to cognitive function, the association between social frailty and long-term cognitive trajectories remains underexplored. This study aims to evaluate the longitudinal association between social frailty and trajectory of cognitive function in dementia-free older adults.
methodsThis prospective cohort study used data from the National Health and Aging Trends Study (NHATS). Social frailty was assessed using the Makizako Social Frailty Index. According to the presence of social components, individuals were categorized into social frailty (≥ 2), pre-social frailty (1), and robust (0), respectively. Cognitive function was annually evaluated through memory, orientation, and executive function tests from 2011 to 2018. Mixed-effects linear models were employed to assess the associations between social frailty and changes in global and domain-specific cognitive function, adjusting for relevant covariates.
resultsIn this study, 4956 dementia-free older adults (mean age 76.57 [7.41]) with complete at least 2 times of cognitive tests were included. Compared with the robust, social frailty was associated with significantly faster decline in global cognitive function (β = -0.041, 95% CI [-0.047, -0.036] z score per year) and domain-specific cognitive function (β
conclusionsSocial frailty is associated with faster decline in cognition in older adults, underscoring the necessity for enhanced social support and engagement to mitigate cognitive deterioration in vulnerable populations.
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