ArticleInfection and immunity1985
Characterization of antibodies mediating protection and cure of Trypanosoma musculi infection in mice.
Article in Infection and immunity, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo.Journal of parasitology research · 2011Article
- Hepatic cells' mitotic and peritoneal macrophage phagocytic activities during Trypanosoma musculi infection in zinc-deficient mice.Journal of the National Medical Association · 1997Article
- Growth of trypanosomes in vivo, host body weight gains, and food consumption in zinc-deficient mice.Journal of the National Medical Association · 1997Article
- Changes in immunoglobulin levels in zinc-deficient mice infected with Trypanosoma musculi.Journal of the National Medical Association · 1994Article
- Antimalarial antibodies of the immunoglobulin G2a isotype modulate parasitemias in mice infected with Plasmodium yoelii.Infection and immunity · 1991Article
- Cells within the vascular system capable of mediating trypanocidal activity in vitro.Infection and immunity · 1991Article
- The liver as a major site of immunological elimination of murine trypanosome infection, demonstrated with the liver perfusion model.Infection and immunity · 1990Article
- Failure to demonstrate a major role for Kupffer cells and radiosensitive leukocytes in immunoglobulin-mediated elimination of Trypanosoma musculi.Infection and immunity · 1990Article
- Further characterization of the curative antibodies in Trypanosoma musculi infection.Infection and immunity · 1988Article
- Cooperative action of complement component C3 and phagocytic effector cells in innate murine resistance to Trypanosoma lewisi.Infection and immunity · 1987Article
- Identification of antibody classes and Fc receptors responsible for phagocytosis of Trypanosoma musculi by mouse macrophages.Infection and immunity · 1986Article
- In vitro assay for curative activity in blood of mice infected with Trypanosoma musculi.Infection and immunity · 1986Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma samples were collected from mice infected with Trypanosoma musculi at different times postinfection and administered to naive recipient mice either before or during T. musculi infection. The protective and curative activities of these plasma samples were shown to increase as the time of collection postinfection increased; plasma collected at 14 days postinfection was partially protective and partially curative, whereas that collected at 28 days postinfection was completely protective and curative. The curative activity was labile to heat treatment (30 min at 56 degrees C), whereas the protective activity was heat stable. Additional kinetic parameters relating to the efficacy of protection were investigated. Evidence is presented that both activities are immunoglobulin in nature. Protein A-Sepharose chromatography indicated that the activities are associated with the immunoglobulin G2a or immunoglobulin G3 subclasses of immunoglobulin G. The curative antibody appears to be intrinsically heat labile, since heat treatment of a purified immunoglobulin preparation abolished the ability to cure. Studies on the mechanism of parasite elimination from blood suggest that the process not only requires antibody but is also complement dependent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.