Green Chemometric-assisted UV spectrophotometric techniques for the analysis of Helicobacter pylori triple therapy: amoxicillin, metronidazole and famotidine in bulk, individual and laboratory- prepared combined dosage forms: application to simulated gastric fluid with comprehensive greenness and whiteness appraisals.

Hadir M Maher, Hoda Mahgoub, Marwa A A Ragab, Salma Tarek

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In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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3 · Its place in the literature

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1 citing paper in PubMed.

Fourier-based chemometric resolution of the FOLFOX regimen through digital filtering with poly-metric sustainability assessment.Scientific reports · 2026
Article

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5 · Who and what money

Authors and funding

4 authors.

Hadir M MaherDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Elmessalah, Alexandria, 21521, Egypt.

Hoda MahgoubDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Elmessalah, Alexandria, 21521, Egypt.

Marwa A A RagabDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Elmessalah, Alexandria, 21521, Egypt. marwa.ragab@alexu.edu.eg.

Salma TarekDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Elmessalah, Alexandria, 21521, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant variable in the genesis of peptic ulcers is Helicobacter pylori, which could be eliminated through several strategies. Amid them, there is a strategy based on receptor histamine-2 (e.g., famotidine) antagonist in conjunction with metronidazole and amoxicillin as antibiotics. This research used UV spectrophotometry paired with chemometrics to clarify the concurrent analysis of famotidine (FAM), amoxicillin (AMX) and metronidazole (MET) in bulk powder and mixed tablet formulations. The first derivative was calculated for determining FAM and MET. Nonetheless, the methods of double divisor ratio spectra and Fourier functions were incorporated for determining each of the three medications. The methods linearity was fine in the strength ranges of 3-20 µg mL

Indexed as

Chemometric-UV spectrophotometric methodologiesFirst derivative and double divisor ratio spectraFourier function based on absorbance dataHelicobacter pylori triple therapy

Identifiers

PMID39972462

DOI10.1186/s13065-025-01387-4

PMCPMC11841278

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