Evidence map›Paper›PMID 39972387›Full record

ArticleAlzheimer's research & therapy2025

Cornuside alleviates cognitive impairments induced by Aβ

Fulin Zhou, Wenwen Lian, Xiaotang Yuan, Zexing Wang, Congyuan Xia, Yu Yan, Wenping Wang, Zhuohang Tong, Yungchi Cheng, Jiekun Xu and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
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  17. Decoding the therapeutic potential mechanism ofFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Fulin Zhou *Institute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China.
Wenwen Lian *Institute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China.
Xiaotang YuanSchool of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People's Republic of China.
Zexing WangSchool of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People's Republic of China.
Congyuan XiaInstitute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China.
Yu YanInstitute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China.
Wenping WangInstitute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China.
Zhuohang TongSchool of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People's Republic of China.
Yungchi ChengDepartment of Pharmacology, School of Medicine, Yale University, Connecticut, New Haven, USA.
Jiekun XuSchool of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People's Republic of China. xjkbucm@163.com.
Jun HeInstitute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China. 15010297582@126.com.
Weiku ZhangInstitute of Clinical Medical Sciences, Department of Pharmacy, China-Japan, Friendship Hospital 2nd, Yinghua Dongjie, Chaoyang District, Beijing, 100029, People's Republic of China. cpuzwk@163.com.

Funding

Central Universities Fundamental for Basic Scientific Research of Peking Union Medical College 3332023096National High Level Hospital Clinical Research Funding & Elite Medical Professionals Project of China-Japan Friendship Hospital 2024-NHLHCRF-JBGS-WZ-07National High Level Hospital Clinical Research Funding & Elite Medical Professionals Project of China-Japan Friendship Hospital ZRJY2023-QM10National High Level Hospital Clinical Research Funding & Elite Medical Professionals Project of China-Japan Friendship Hospital ZRJY2023-QM28National High Level Hospital Clinical Research Funding & Elite Medical Professionals Project of China-Japan Friendship Hospital ZRJY2024-BJ01National Natural Science Foundation of China 82273809National Natural Science Foundation of China 82273815National Natural Science Foundation of China 82404883
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which mitochondrial dysfunction and neuroinflammation play crucial roles in its progression. Our previous studies found that cornuside from Cornus officinalis Sieb.Et Zucc is an anti-AD candidate, however, its underlying mechanism remains unknown. In the present study, AD mice were established by intracerebroventricular injection of Aβ

Indexed as

Amyloid beta-PeptidesCognitive DysfunctionMitophagyNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinPeptide FragmentsAnimalsDisease Models, AnimalInflammasomesMaleMiceMice, Inbred C57BLNeuronsAmyloid beta-Peptidesamyloid beta-protein (1-42)InflammasomesNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePeptide FragmentsAlzheimer’s diseaseCornusideMitophagyNeuroprotectionNLRP3

Identifiers

PMID39972387
PMCPMC11837312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.