Evidence map›Paper›PMID 39972354›Full record

ArticleTrials2025

Time to return of bowel function following perioperative probiotics in colorectal cancer surgery (PICCS-1): study protocol for a randomized controlled trial.

Dedrick Kok Hong Chan, Bei En Siew, Jerrald Lau, Jasmin Koh, Megan Xin-Hui Lee, Chermaine Ang, Ning Qi Pang, Ker-Kan Tan

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06456229 (Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06456229 naunknown statusnot on this map

Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery (PICCS-1)

TypeinterventionalSponsorNational University Hospital, SingaporeRan2024 to 2025Enrolled162ConditionsColorectal Cancer, Ileus Postoperative, Flatus, Diet, HealthyArmsNestle Isocal, Nestle Boost Optimum
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dedrick Kok Hong ChanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. surckhd@nus.edu.sg.ORCID http://orcid.org/0000-0002-4237-8648
Bei En SiewDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jerrald LauDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jasmin KohDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Megan Xin-Hui LeeDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chermaine AngDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ning Qi PangDivision of Hepatobiliary Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore.
Ker-Kan TanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative ileus occurs in up to 30% of patients following major oncologic surgery for colorectal cancer, leading to significant morbidity, patient distress, as well as increased utilization of healthcare resources. Various modalities to reduce postoperative ileus rates have been explored. One such modality is the perioperative administration of probiotics which have hitherto achieved inconsistent success. Here, we design a trial to determine whether the perioperative administration with probiotics given together with nutritional supplementation can help to reduce postoperative ileus rates.

methodsWe propose a parallel three-arm randomized controlled trial. In Arm 1, no nutritional supplementation is provided to the patient. In Arm 2, Nestle Isocal is provided to the participant. Nestle Isocal provides nutritional supplementation but without any probiotic. In Arm 3, Nestle Boost Optimum is provided to the patient. Nestle Boost Optimum contains a similar nutritional profile to Isocal, but with the addition of Lactobacillus paracasei. The primary outcome is the time to first bowel movement in days from the day of surgery. Secondary outcomes are time to first flatus, infective complications, and adverse events related to the administration of nutritional supplementation. Statistical analysis will be conducted in an intention-to-treat approach. ANOVA with the Tukey test will be used to compare continuous variables, while the χ DISCUSSION: Nutritional supplementation with probiotics is a convenient, non-pill alternative for patients. Furthermore, the interventions are commonly found in the formulary of many hospitals worldwide. If successful, probiotics in nutritional supplementation could be a cost-effective and simple way to reduce postoperative ileus.

trial registrationClinicalTrials.gov NCT06456229. This trial was registered on 11 June 2024. Thai Clinical Trials Registry TCTR20240706003. This trial was registered on 6 July 2024.

Indexed as

Colorectal NeoplasmsDefecationIleusPerioperative CarePostoperative ComplicationsProbioticsDietary SupplementsDigestive System Surgical ProceduresHumansRandomized Controlled Trials as TopicRecovery of FunctionTime FactorsTreatment OutcomeColorectal cancerColorectal surgeryComplicationsLength of stayNutritional supplementationProbioticsTime to bowel movementTime to flatus

Identifiers

PMID39972354
PMCPMC11837682

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.