ArticleBMC oral health2025
Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1/Hes1 signaling pathway expression.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cone-beam CT analysis of temporomandibular joint morphology before and after rehabilitation in patients with Kennedy class II partial edentulism.Odontology · 2026Article
- Piezo1/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption.Journal of molecular medicine (Berlin, Germany) · 2026Article
- The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis.Cell communication and signaling : CCS · 2025Review
- Alterations in the Temporomandibular Joint Space Following Orthognathic Surgery Based on Cone Beam Computed Tomography: A Systematic Review.Journal of clinical medicine · 2025Review
- Roles of VWA1 and Rac2 in compensatory and decompensatory responses via FGF9/FGFR3 and p38 MAPK signaling pathways in condylar chondrocytes under distinct mechanical stress.Arthritis research & therapy · 2025Article
- Tomographic assessment of glenoid fossa morphology and position in symmetric and asymmetric patients.Science progressObservational
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6 authors.
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Abstract
objectiveWe aimed to assess the impact of unbalanced occlusal loading on the TMJ and the expression of the Notch1/Hes1 signaling pathway using a unilateral occlusal loss rat model.
methodsWe established a unilateral occlusal defect animal model. At three different times, all female Wistar rats were randomized into three groups (4 weeks, 6 weeks, and 10 weeks): (1) unilateral occlusal loss experiment group (extraction of the left mandibular molars and trimming of the left mandibular incisors every other day), (2) restoring incisal occlusion experiment group (extraction of the left mandibular molars and trimming of the left mandibular incisors every other day for 4 weeks, and then the incisor trimming was stopped until 10 weeks), (3) control group (normal loading). Micro-CT, histological staining, immunofluorescence, immunohistochemistry, and real-time quantitative polymerase chain reaction were used to identify changes in condylar cartilage, subchondral bone, and articular discs.
resultsTemporomandibular joint condylar cartilage degradation was induced by unbalanced occlusal loading, especially on the extraction side. The dropped cartilage thickness, Cyclin D1 positive chondrocytes, TB staining and collagen II positive areas, the decreased expression levels of Notch1, Jagged1, and Hes1 in condylar cartilage, the loss of TMJ subchondral bone were all reversed in the restoring incisal occlusion experiment group at 6 weeks. The experiment group exhibited catabolic degradative alterations at the molecular level in TMJ discs, showing a notable decrease in the mRNA expression levels of Col I, Col II, and ALP.
conclusionsThe growing rat TMJ condyle exhibits a significant remodeling capacity in altered occlusal loading, which can be degenerative and recuperative, respectively, in reaction to decreased occlusal loading and restored occlusal loading. Appropriate occlusal loading is essential for transducing the Notch1/Hes1 signaling pathway and normal metabolism of the TMJ disc.
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