ArticleBMC oral health2025
Changes in MMP-9, T-SOD and SIRT-1 levels after non-surgical periodontal treatment.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06255470 (Effect of Periodontal Treatment on Salivary and Serum SIRT-1, MMP-9 and T-SOD Levels), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Periodontal Treatment on Salivary and Serum SIRT-1, MMP-9 and T-SOD Levels
Who cites it
3 citing papers in PubMed.
- The JNJ0966 Significantly Reduces the Elevated Serum MMP-9 and Blood Pressure Observed in SHRs With Periodontitis.International dental journal · 2026Article
- Differential Response of Salivary MMP-8 and MMP-9 to Full-Mouth Disinfection: Implications for Biomarker Sensitivity in Periodontal Therapy.Dentistry journal · 2026Article
- Association Between Salivary Sirtuin-1 Levels and Periodontitis.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix metalloproteinase-9 (MMP-9), total superoxide dismutase (T-SOD) and sirtuin (SIRT)-1 are interrelated molecules linked with oxidative stress and periodontitis pathogenesis which may have implications for both the diagnosis of periodontitis or efficacy of periodontal treatment. This study aimed to evaluate salivary and serum MMP-9, T-SOD, and SIRT-1 levels in stage 3 periodontitis patients (P-S3) following non-surgical periodontal treatment (NSPT).
methodsForty-nine subjects, comprising 17 healthy, 16 P-S3 Grade B (P-S3GB), and 16 P-S3 Grade C (P-S3GC) subjects, participated in the study. Clinical periodontal parameters, salivary and serum MMP-9, T-SOD and SIRT-1 levels were evaluated at baseline from all participants and at 3-months from periodontitis patients. Enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of the biochemical parameters.
resultsAll clinical periodontal parameters improved in both periodontitis groups (p < 0.05) after NSPT. In P-S3GB and GC groups, salivary levels of MMP-9 and T-SOD were higher than healthy controls (p < 0.05) and decreased following NSPT (p < 0.05). P-S3GC group had higher serum MMP-9 levels than the healthy ones (p < 0.05). Salivary SIRT-1 and serum T-SOD levels were similar among groups (p > 0.05). After NSPT, only in P-S3GB group, salivary SIRT-1 decreased, and serum T-SOD increased (p < 0.05). Salivary T-SOD and MMP-9 showed positive correlations with clinical parameters (p < 0.05).
conclusionsThe study results suggest that MMP-9 and T-SOD are potential biomarkers for diagnosing P-S3GB and GC and evaluating the efficacy of NSPT. However, further research is necessary to validate these findings across all grades and stages of periodontitis.
trial registrationThis study was retrospectively registered on 13/02/2024 at Clinical trials.gov with the number NCT06255470.
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