ArticleNature medicine2025
Integrating the environmental and genetic architectures of aging and mortality.
Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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Who cites it
132 citing papers in PubMed.
- Main Outcomes of the HEBE Trial: Improving Cardiorespiratory Fitness and Body Composition Through a Tailored Feasible Lifestyle Program.Nutrients · 2026Trial
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- Ageing, women's health and personalised medicine: Advancing artificial intelligence and therapeutics through the blueprint theory paradigm.Experimental physiology · 2026Article
- Evolution expresses the second law of thermodynamics in action.Journal of the Royal Society, Interface · 2026Article
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- Artificial Intelligence as a Core Public Health Competency: Proposal and Perspectives in Education and Research.JMIR medical education · 2026Article
- Polygenic risk scores in human genetics for study design discovery and translation.Human genetics · 2026Review
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Sex-specific biological aging clocks across organs and omics.Nature medicine · 2026Article
- Article
- Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging.Nature communications · 2026Article
- Enhancing Healthy Longevity: Scoping Review of Practices and Interventions.Interactive journal of medical research · 2026Review
- Association Between Cardiorespiratory Fitness and a Composite Index of Cardiac Autonomic Control: Potential Implications for Exercise Training Evaluation.Journal of clinical medicine · 2026Article
- Letter to the Editor: Reimagining environmental health for children - integrating longitudinal, genetic, and cross-cultural perspectives.Child and adolescent mental health · 2026Article
- Tackling aging and chronic disease: How space exploration and the 'chameleon effect' of pharmaceuticals can lead the way.Experimental physiology · 2026Review
- Column switching liquid chromatography dual mass spectrometry system for simultaneous untargeted metabolomics and targeted exposomics.Nature communications · 2026Article
- A Lifestyle Behavior Score Predicting Cardiovascular and Other Causes of Death in a Cohort of Middle-Aged Men Followed up Until Extinction.Journal of cardiovascular development and disease · 2026Article
- Biological Aging, Immune Phenotypes, and Susceptibility to COVID-19 and Sepsis: A Mendelian Randomization Study.Virus research · 2026Article
- The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis of all-cause mortality (n = 492,567) and then assessed the associations of these exposures with a proteomic age clock (n = 45,441), identifying 25 independent exposures associated with mortality and proteomic aging. These exposures were also associated with incident age-related multimorbidity, aging biomarkers and major disease risk factors. Compared with information on age and sex, polygenic risk scores for 22 major diseases explained less than 2 percentage points of additional mortality variation, whereas the exposome explained an additional 17 percentage points. Polygenic risk explained a greater proportion of variation (10.3-26.2%) compared with the exposome for incidence of dementias and breast, prostate and colorectal cancers, whereas the exposome explained a greater proportion of variation (5.5-49.4%) compared with polygenic risk for incidence of diseases of the lung, heart and liver. Our findings provide a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk, irrespective of polygenic disease risk.
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Registered trials
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