Evidence map›Paper›PMID 39972177›Full record

Observational studyHypertension research : official journal of the Japanese Society of Hypertension2025

Combined effects of hypertension and arterial stiffness on target organ damage among community-based screening participants.

Yoshitsugu Sunagawa, Akio Ishida, Masanobu Yamazato, Yusuke Ohya, Kenya Kusunose

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Striving toward effective management of target organ damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yoshitsugu SunagawaDepartment of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Akio IshidaDepartment of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. yaican@med.u-ryukyu.ac.jp.
Masanobu YamazatoOkinawa Health Promotion Foundation, Okinawa, Japan.
Yusuke OhyaUniversity of the Ryukyus Hospital, Okinawa, Japan.
Kenya KusunoseDepartment of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the impact of hypertension and high pulse wave velocity (PWV), each assessed in a single measurement, on target organ damage, proteinuria, and left ventricular hypertrophy (LVH). This observational cross-sectional study included 13,186 patients who underwent brachial-ankle PWV (baPWV) measurement, urinalysis, and electrocardiography during a health check-up. Blood pressure (BP) was measured at the time of baPWV measurement. Proteinuria and LVH were evaluated using a urine dipstick test and electrocardiography, respectively. Participants were categorized into four groups based on their hypertension (yes/no, defined as BP ≥ 140/90 mmHg) and baPWV (high/low, cutoff value of 14.0 m/s) statuses. The mean age of the participants was 53 ± 11 years, and the prevalence of proteinuria and LVH was 594 (4.5%) and 1716 (13.0%), respectively. Compared with the non-hypertension with low baPWV group, the non-hypertension with high baPWV (odds ratio [OR] 1.41 [95% confidence interval (CI), 1.07-1.86]), hypertension with low baPWV (OR 2.66 [95% CI, 1.78-3.97]), and hypertension with high baPWV groups (OR 2.80 [95% CI, 2.18-3.61]) exhibited a higher multivariate-adjusted risk for proteinuria. The hypertension with low baPWV group had a significantly higher risk of proteinuria than the non-hypertension with high baPWV group. Similar results were obtained for LVH. Hypertension and a high baPWV were independently associated with the prevalence of proteinuria and LVH. Hypertension assessed in a single BP measurement is likely to be a more important risk factor for proteinuria and LVH than high baPWV. Hypertension and high brachial-ankle pulse wave velocity were independently associated with the prevalence of proteinuria and left ventricular hypertrophy. Hypertension assessed in a single blood pressure measurement is likely to be a more important risk factor for proteinuria and left ventricular hypertrophy than high brachial-ankle pulse wave velocity.

Indexed as

HypertensionHypertrophy, Left VentricularProteinuriaVascular StiffnessAdultAgedAnkle Brachial IndexBlood PressureCross-Sectional StudiesElectrocardiographyFemaleHumansMaleMiddle AgedPulse Wave AnalysisBlood pressureLeft ventricular hypertrophyProteinuriaPulse wave velocityVascular stiffness

Identifiers

PMID39972177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.