ArticleNature2025
Endogenous DNA damage at sites of terminated transcripts.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Double strand breaks drive toxicity in a Huntington's disease mouse model with or without somatic expansion.Nature communications · 2026Article
- R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers.Nature communications · 2026Article
- Emerging drivers of DNA repeat expansions.Biochemical Society transactions · 2025Review
- GoldenBraid2.0Synthetic biology (Oxford, England) · 2025Article
- Genomic mapping of DNA-repair reaction intermediates in living cells with engineered DNA structure-trap proteins.Methods in enzymology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Jingjing LiuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jullian O PerrenDepartment of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-1705-3446
Cody M RogersDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Sadeieh NimerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Alice X WenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3572-0481
Jennifer A HallidayDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Devon M FitzgeraldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2480-7269
Qian MeiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ralf B NehringDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5156-7734
Mary CrumDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Stanislav G KozminDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jun XiaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Matthew B CookeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-0964-2715
Yin ZhaiDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
David BatesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Lei LiDepartment of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-1196-6372
P J HastingsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Irina ArtsimovitchDepartment of Microbiology, Ohio State University, Columbus, OH, USA.ORCID 0000-0002-8604-0980
Christophe HermanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8954-7907
Patrick M SungDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0003-1396-9040
Kyle M MillerDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. kyle.m.miller@emory.edu.ORCID 0000-0002-4544-0013
Susan M RosenbergDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. smr@bcm.edu.ORCID 0000-0003-1444-473X
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI KLINE, MARK W. · 1994 to 2015
$21.7MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MMechnanism of transcript elongation control by RfaHR01GM067153 · NIGMS · OHIO STATE UNIVERSITY · PI IRINA ARTSIMOVITCH · 2003 to 2026
$8.0MMOLECULAR MECHANISMS /STRESS-INDUCED MUTATION /E. COLIR01GM053158 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 1997 to 2014
$7.4MMechanisms of DNA Homology-directed Genome Repair and Tumor SuppressionR35CA241801 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SUNG, PATRICK · 2019 to 2025
$6.0MHarnessing Proteins as Drugs: the Protectome of Cancer- and Aging-Prevention ProteinsDP1AG072751 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ROSENBERG, SUSAN M · 2020 to 2024
$5.6MA Synthetic Platform for Non-Antibiotic Eradication of Bacterial InfectionsDP1AI152073 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI HERMAN, CHRISTOPHE · 2019 to 2023
$5.6MMechanisms of Endogenous DNA Damage PromotionR01CA250905 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MILLER, KYLE M, ROSENBERG, SUSAN M · 2020 to 2024
$3.3MMUTATIONAL SIGNATURE(S) OF HUMAN GENOMIC REARRANGEMENT MECHANISMSR01GM106373 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI HASTINGS, PHILIP JOHN, LUPSKI, JAMES R. · 2014 to 2022
$3.1MNCI NIH HHS P30 CA125123NCI NIH HHS R01 CA250905NCI NIH HHS R35 CA241801NCRR NIH HHS S10 RR024574NIAID NIH HHS DP1 AI152073NIAID NIH HHS P30 AI036211NIA NIH HHS DP1 AG072751NIA NIH HHS T32 AG021890NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R00 ES033259NIGMS NIH HHS R01 GM053158NIGMS NIH HHS R01 GM067153NIGMS NIH HHS R01 GM106373NIGMS NIH HHS R01 GM135368
Abstract
DNA damage promotes mutations that fuel cancer, ageing and neurodegenerative diseases
Indexed as
DNA DamageTranscription, GeneticTranscription Termination, GeneticDNA Breaks, Double-StrandedDNA-Directed RNA PolymerasesDNA Polymerase IIIDNA ReplicationDNA, Single-StrandedEscherichia coliHumansDNA-Directed RNA PolymerasesDNA Polymerase IIIDNA, Single-Stranded
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.