Evidence map›Paper›PMID 39972139›Full record

ArticleNature2025

Plasmodium blood stage development requires the chromatin remodeller Snf2L.

Maria Theresia Watzlowik, Elisabeth Silberhorn, Sujaan Das, Ritwik Singhal, Kannan Venugopal, Simon Holzinger, Barbara Stokes, Ella Schadt, Lauriane Sollelis, Victoria A Bonnell and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria Theresia WatzlowikRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.
Elisabeth SilberhornRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.
Sujaan DasExperimental Parasitology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany.
Ritwik SinghalDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, State College, PA, USA.
Kannan VenugopalInstitute of Parasitology, Vetsuisse and Medical faculty, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1620-5524
Simon HolzingerRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0009-0003-0651-4563
Barbara StokesInstitute of Parasitology, Vetsuisse and Medical faculty, University of Zurich, Zurich, Switzerland.
Ella SchadtExperimental Parasitology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany.ORCID http://orcid.org/0009-0000-4572-3489
Lauriane SollelisInstitute of Parasitology, Vetsuisse and Medical faculty, University of Zurich, Zurich, Switzerland.
Victoria A BonnellDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, State College, PA, USA.
Matthew GowExperimental Parasitology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany.
Andreas KlinglPlant Development, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0001-8414-8317
Matthias MartiInstitute of Parasitology, Vetsuisse and Medical faculty, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1040-9566
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, State College, PA, USA.
Markus MeissnerExperimental Parasitology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany. markus.meissner@lmu.de.ORCID http://orcid.org/0000-0002-5341-5969
Gernot LängstRegensburg Center for Biochemistry (RCB), University of Regensburg, Regensburg, Germany. gernot.laengst@ur.de.ORCID http://orcid.org/0000-0002-8232-1179

Funding

Eukaryotic Gene Regulation (EGR) Predoctoral Training ProgramT32GM125592 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI REESE, JOSEPH C · 2018 to 2022
$920k
NIGMS NIH HHS T32 GM125592Wellcome Trust
6 · The paper itself

Abstract

The complex life cycle of the malaria parasite Plasmodium falciparum involves several major differentiation stages, each requiring strict control of gene expression. Fundamental changes in chromatin structure and epigenetic modifications during life cycle progression suggest a central role for these mechanisms in regulating the transcriptional program of malaria parasite development

Indexed as

Adenosine TriphosphatasesChromatin Assembly and DisassemblyLife Cycle StagesPlasmodium falciparumProtozoan ProteinsAnimalsAntimalarialsChromatinErythrocytesHumansMalaria, FalciparumNucleosomesPromoter Regions, GeneticTranscription FactorsTranscription, GeneticAdenosine TriphosphatasesAntimalarialsChromatinNucleosomesProtozoan ProteinsTranscription Factors

Identifiers

PMID39972139
PMCPMC11946908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.