Evidence map›Paper›PMID 39972132›Full record

ArticleNature2025

GABAergic neuron-to-glioma synapses in diffuse midline gliomas.

Tara Barron, Belgin Yalçın, Minhui Su, Youkyeong Gloria Byun, Avishai Gavish, Kiarash Shamardani, Haojun Xu, Lijun Ni, Neeraj Soni, Vilina Mehta and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tara BarronDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Belgin YalçınDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9689-9062
Minhui SuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5803-6098
Youkyeong Gloria ByunDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4669-0855
Avishai GavishDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kiarash ShamardaniDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2548-705X
Haojun XuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Lijun NiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Neeraj SoniDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4191-6723
Vilina MehtaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5211-7505
Samin Maleki JahanDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Yoon Seok KimDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kathryn R TaylorDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5110-8703
Michael B KeoughDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Michael A QuezadaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7307-5204
Anna C GeraghtyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Rebecca MancusiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4809-5569
Linh Thuy VoDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Enrique Herrera CastañedaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Pamelyn J WooDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Claudia K PetritschDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3442-4974
Hannes VogelDepartment of Pathology, Stanford University, Stanford, CA, USA.
Kai KailaFaculty of Bio- and Environmental Sciences (MIBS), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-0668-5955
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.ORCID 0000-0002-3547-237X

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KEITH LLOYD LIGON · 2013 to 2026
$33.5M
Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
eDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7M
Targeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL J ECK · 2021 to 2026
$6.4M
Glioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7M
Developing Safe and Effective GD2-CAR T Cell Therapy for Diffuse Midline GliomasR01CA263500 · NCI · STANFORD UNIVERSITY · PI MACKALL, CRYSTAL, MONJE-DEISSEROTH, MICHELLE · 2021 to 2025
$3.3M
Neuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1M
Neuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1M
NCI NIH HHS OT2 CA278688NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA258384NCI NIH HHS R01 CA263500NCI NIH HHS T32 CA009302NCI NIH HHS U19 CA264504NINDS NIH HHS DP1 NS111132NINDS NIH HHS R01 NS092597
6 · The paper itself

Abstract

High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M-altered diffuse intrinsic pontine glioma, and hemispheric HGGs, such as IDH wild-type glioblastoma. Neuronal activity drives glioma progression through paracrine signalling

Indexed as

Brain NeoplasmsGABAergic NeuronsGliomaSynapsesAnimalsCell Line, TumorCell ProliferationFemalegamma-Aminobutyric AcidHumansMaleMiceOptogeneticsReceptors, GABA-ASolute Carrier Family 12, Member 2gamma-Aminobutyric AcidReceptors, GABA-ASolute Carrier Family 12, Member 2

Identifiers

PMID39972132
PMCPMC11946904

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.