Evidence map›Paper›PMID 39972131›Full record

ArticleNature2025

Cooperative nutrient scavenging is an evolutionary advantage in cancer.

Gizem Guzelsoy, Setiembre D Elorza, Manon Ros, Logan T Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S Brunner, Ray Pillai, William E Walkowicz and 4 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
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  7. Article
  8. Review
  9. Article
  10. Tumor-Targeted Delivery Therapy Based on PLGA Nanoparticles.Journal of functional biomaterials · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gizem Guzelsoy *Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.ORCID 0000-0002-6227-3501
Setiembre D Elorza *Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Manon RosCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.ORCID 0000-0001-7878-3613
Logan T SchachtnerCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Makiko HayashiDepartment of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Spencer Hobson-GutierrezCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Parker RundstromCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA.
Julia S BrunnerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-3195-147X
Ray PillaiDepartment of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID 0000-0002-8335-3463
William E WalkowiczChemitope Glycopeptide, Brooklyn, NY, USA.
Lydia W S FinleyCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4023-7574
Maxime DeforetSorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Laboratoire Jean Perrin (LJP), Paris, France.
Thales PapagiannakopoulosDepartment of Pathology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID 0000-0002-2251-1624
Carlos Carmona-FontaineCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, USA. cf97@nyu.edu.ORCID 0000-0002-5238-6852

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Decoding the fundamental mechanisms of tumor emergence and evolutionDP2CA250005 · NCI · NEW YORK UNIVERSITY · PI CARMONA-FONTAINE, CARLOS · 2019 to 2019
$2.4M
NCI NIH HHS DP2 CA250005NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NICHD NIH HHS T32 HD007520
6 · The paper itself

Abstract

The survival of malignant cells within tumours is often seen as depending on ruthless competition for nutrients and other resources

Indexed as

Biological EvolutionNeoplasmsNutrientsAmino AcidsAminopeptidasesAnimalsCell Line, TumorCell ProliferationCell SurvivalFemaleHumansHydrolysisMiceMice, Inbred C57BLOligopeptidesTumor MicroenvironmentAmino AcidsAminopeptidasesNutrientsOligopeptides

Identifiers

PMID39972131
PMCPMC11981941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.