Evidence map›Paper›PMID 39972126›Full record

ArticleNature2025

A dual-pathway architecture for stress to disrupt agency and promote habit.

Jacqueline R Giovanniello, Natalie Paredes, Anna Wiener, Kathia Ramírez-Armenta, Chukwuebuka Oragwam, Hanniel O Uwadia, Abigail L Yu, Kayla Lim, Jenna S Pimenta, Gabriela E Vilchez and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  8. Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  9. Goal-directed actions and habits in head-fixed mice.Frontiers in behavioral neuroscience · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jacqueline R GiovannielloDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Natalie ParedesDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Anna WienerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Kathia Ramírez-ArmentaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Chukwuebuka OragwamDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Hanniel O UwadiaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0003-7425-8469
Abigail L YuDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0000-2194-5028
Kayla LimDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7168-5877
Jenna S PimentaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Gabriela E VilchezDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Gift NnamdiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Alicia WangDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Megha SehgalDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Fernando McV ReisDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0121-2887
Ana C SiasDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Alcino J SilvaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1587-4558
Avishek AdhikariDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9187-9211
Melissa MalvaezDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Kate M WassumDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. kwassum@ucla.edu.ORCID 0000-0002-2635-7433

Funding

BUILD PODER IITL4GM118977 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHAVIRA, GABRIELA, KHACHIKIAN, CRIST SIMON · 2015 to 2023
$18.1M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael Gandal · 2020 to 2026
$9.6M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Basolateral Amygdala Rapid Glutamate Signaling During Reward Decision-MakingR01DA035443 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kate M Wassum · 2013 to 2026
$5.7M
Epigenetic Regulation Of Striatal Circuit Function For Action And Habit LearningR01DA046679 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASSUM, KATE M · 2019 to 2023
$2.7M
Dissection of Hypothalamic-Brainstem Circuits in Panic-Related Escape BehaviorR01MH119089 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADHIKARI, AVISHEK · 2019 to 2023
$2.1M
Do opposing amygdala-striatal pathways enable chronic stress to promote habit formation?R01DA058374 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kate M Wassum · 2024 to 2026
$1.8M
Revealing the neural mechanisms of amygdala-striatal control of stress-induced habitsR00MH135177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Jacqueline Giovanniello · 2025 to 2026
$466k
Revealing the neural mechanisms of amygdala-striatal control of stress-induced habitsK99MH135177 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIOVANNIELLO, JACQUELINE · 2024 to 2025
$126k
Examining the neuronal mechanisms underlying stress-accelerated habitF32DA056201 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIOVANNIELLO, JACQUELINE · 2022 to 2022
$49k
NICHD NIH HHS P50 HD103557NIDA NIH HHS F32 DA056201NIDA NIH HHS R01 DA035443NIDA NIH HHS R01 DA046679NIDA NIH HHS R01 DA058374NIDA NIH HHS T32 DA024635NIGMS NIH HHS TL4 GM118977NIMH NIH HHS K99 MH135177NIMH NIH HHS L40 MH137809NIMH NIH HHS R00 MH135177NIMH NIH HHS R01 MH119089
6 · The paper itself

Abstract

Chronic stress can change how we learn and, thus, how we make decisions

Indexed as

HabitsLearningNeural PathwaysStress, PsychologicalAmygdalaAnimalsChronic DiseaseCorpus StriatumDecision MakingFemaleGoalsMaleMiceMice, Inbred C57BLReward

Identifiers

PMID39972126
PMCPMC12011321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.