Evidence map›Paper›PMID 39972113›Full record

ArticleScientific reports2025

Identification of shared genetic loci for asthma, allergic rhinitis, and pollinosis in East Asians.

Dong Wang, Shuai Liu, Qinfeng Wu, Yue Jiang, Chumeng Zhang, Weiyi Ye, Bichen Peng, Haoran Xie, Wen Li, Yue Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dong WangJinan Engineering Polytechnic, Jinan, China.
Shuai LiuAgricultural Products Quality and Safety Center of Jinan, Jinan, China.
Qinfeng WuCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Yue JiangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Chumeng ZhangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Weiyi YeCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Bichen PengCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Haoran XieCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Wen LiCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Yue WangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China.
Lili ZhiDepartment of Allergy, Shandong Institute of Respiratory Diseases, the First Affiliated Hospital of Shandong First Medical University, Jinan, China. qfsyyallergy@163.com.
Xiao ChangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, China. changxiao@sdfmu.edu.cn.
Lei ShaoDepartment of Infectious Disease, Central Hospital Affiliated to Shandong First Medical University, Jinan, China. shaolei0328@163.com.

Funding

Taishan Scholar Foundation of Shandong Province tsqn202211224
6 · The paper itself

Abstract

Asthma, allergic rhinitis, and pollinosis are prevalent respiratory conditions that often co-occur, suggesting common genetic and environmental causes. While significant progress has been made in identifying genetic loci in European populations, the genetic architecture in East Asian populations remains poorly understood. Using GWAS summary statistics from BioBank Japan, we performed multi-trait genome-wide association studies (MTAG) to quantify the genetic overlap among asthma, allergic rhinitis, and pollinosis in East Asians. Genetic correlation analysis revealed significant positive correlations among the three conditions, and stratified LDSC (Linkage Disequilibrium Score Regression) analysis identified heritability enrichments in Blood/Immune and Digestive tissues. We discovered novel pleiotropic loci at 9q32 and 10q25.2 specific to East Asians, with candidate gene expression analysis highlighting differential expression of AKNA, ATP6V1G1, and GPAM. These findings provide new insights into the shared genetic architecture and biological mechanisms underlying these conditions, advancing our understanding of their genetic determinants and identifying potential therapeutic targets.

Indexed as

AsthmaGenetic LociRhinitis, AllergicRhinitis, Allergic, SeasonalEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanLinkage DisequilibriumMalePolymorphism, Single Nucleotide

Identifiers

PMID39972113
PMCPMC11840148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.