ArticleNPJ digital medicine2025
Randomized controlled study of a digital data driven intervention for depressive and generalized anxiety symptoms.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Harnessing digital health interventions to address the heterogeneity of depression: a systematic review.Frontiers in digital health · 2025Pooled it
- Efficacy of a Smartphone-Based Digital Therapeutic (Anzeilax) in Generalized Anxiety Disorder: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Who gets included? Equity in digital and decentralised mental health and neurodevelopmental trials: A systematic review.PLOS digital health · 2026Article
- Digital Physical Activity Interventions for Mental Health Promotion of and Reduction in Addictive Behaviors: Integrative Comprehensive Review with a Focus on Personalization and Implementation.International journal of environmental research and public health · 2026Review
- Neuropsychological Mechanisms Associated with the Effectiveness of AI-Delivered Health Promotion Programs: A Comprehensive Meta-Analysis.Brain sciences · 2026Review
- Effectiveness of digital and mobile-based interventions on sleep quality among nurses: a systematic review and meta-analysis.Frontiers in digital health · 2026Review
- Transdiagnostic-focused apps for depression and anxiety: a meta-analysis.NPJ digital medicine · 2025Article
- Transformer-Based Decomposition of Electrodermal Activity for Real-World Mental Health Applications.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As mental health disorders like Major Depressive Disorder and Generalized Anxiety Disorder rise globally, effective, scalable, and personalized treatments are urgently needed. This 16-week prospective, decentralized, randomized, waitlist-controlled study investigated the effectiveness of a digital data-driven therapeutic integrating wearable sensor data with a mobile app to deliver personalized CBT-based interventions for individuals with depressive and generalized anxiety symptoms. 200 adults were randomized to intervention or control groups, with 164 completing the study. The intervention group demonstrated significant reductions in depressive (mean change = -5.61, CI = -7.14, -4.08) and anxiety symptoms (mean change = -5.21, CI = -6.66, -3.76), compared to the control group, with medium-to-large effect sizes (r = 0.64 and r = 0.62, P < 0.001). Notably, these improvements were also observed in participants with clinically significant depression and anxiety, further reinforcing the potential of digital therapeutics in targeting more severe cases. These findings, combined with high engagement levels, suggest that data-driven digital health interventions could complement traditional treatments, though further research is needed to assess their long-term impact.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.