ArticleScientific reports2025
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Servo-Actuated 3D-Printed Disposable Microvalves for Automated, Scalable Organoid Culture in Standard Incubators.bioRxiv : the preprint server for biology · 2026Article
- Paper-based microfluidics for wearable soft bioelectronics.Lab on a chip · 2026Review
- Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors.Cancer metastasis reviews · 2026Review
- A 3D-Printed Pump-Free Multi-Organ-on-a-Chip Platform for Modeling the Intestine-Liver-Muscle Axis.Micromachines · 2026Article
- A review of organ-on-chip fabrication methods: From early developments to overcoming inert barriers.iScience · 2025Review
- The 3D Printing of Flexible Materials: Technologies, Materials, and Challenges.Materials (Basel, Switzerland) · 2025Review
- Strain-Adaptive Liquid Metal Interfaces Overcome Poisson's Ratio Constraints in Piezoresistive Sensors for Infant Sleep Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Taguchi-Based Optimization of FDM Parameters for Sub-150 µm Microchannels: Comparative Study of PETG and TPU.Micromachines · 2025Article
- Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment.Polymers · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The development of cost-effective, flexible, and scalable microfluidic devices is crucial for advancing organ-on-a-chip (OoC) technology for drug discovery and disease modeling applications. In this study, we present a novel 3D-printed flexible microfluidic device (3D-FlexTPU-MFD) fabricated through a one-step fused deposition modeling (FDM) process using thermoplastic polyurethane (TPU) as the printing filament and polyvinyl chloride (PVC) as the bonding substrate. The device's compatibility was evaluated with various cell types, including human primary myoblasts, human primary endothelial cells (HUVEC), and human iPSC-derived optic vesicle (OV) organoids. Myoblasts cultured within the device exhibited high viability, successful differentiation, and the formation of aligned myotube bundles, outperforming conventional well-plate cultures. Additionally, iPSC-derived OV organoids-maintained viability, displayed neurite outgrowth, and sustained expression of the eye marker PAX6. These results demonstrate that the 3D-FlexTPU-MFD effectively supports cell growth, differentiation, and alignment, making it a promising platform for tissue modeling and OoC applications in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.