ArticleNature communications2025
Organelle-like structural evolution of coacervate droplets induced by photopolymerization.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Patchy Membrane-Directed Multiphase Complex Coacervation.Journal of the American Chemical Society · 2026Article
- Peptide-Metal Cation Coacervate Microdroplets as Membrane-free Protocells with Enhanced Light-Induced Catalysis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Photoactivated Signaling Networks using DNA-Based Synthetic Organelles as Biomimetic Protocells.Angewandte Chemie (International ed. in English) · 2026Article
- Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026Review
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Reconfiguration of Multiphase Coacervate Droplets Into Self-Regulated Nested Artificial Cells.Angewandte Chemie (International ed. in English) · 2026Article
- Recent advances in coacervate protocells from passive catalysts to chemically programmable systems.Communications chemistry · 2026Review
- Spontaneous Fusion of Aqueous Two-Phase Droplets: Effect of Coexisting Phospholipids on Stability.Chembiochem : a European journal of chemical biology · 2025Article
- Light-induced self-adaptive growth of photonic crystal structures in perfluorosulfonic acid ionomer films.Nature communications · 2025Article
- Article
- Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery.Bioactive materials · 2025Review
- Dual-Stimulus Programmed Multiphase Separation and Organization in Coacervate Droplets.Angewandte Chemie (International ed. in English) · 2025Article
- Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamic study of coacervates in vitro contributes our understanding of phase separation mechanisms in cells due to complex intracellular physiology. However, current researches mainly involve the use of exogenous auxiliary agents to form multi-compartmental coacervates with short-term stability. Herein, we report the endogenous self-organizing of multi-component coacervates (HA/PDDA/BSA/DMAEMA) induced by a dynamic stimulation process of protein-mediated photopolymerization. As polymerization proceeds, the cycled structural evolution and maturation from coacervate droplets into multi-compartmental coacervates, coacervate vesicles and coacervate droplets are revealed, which are driven by electrostatic interaction and osmotic pressure difference supported by dynamic and thermodynamic control. Specially, by regulating the light stimulation time, a type of multi-compartmental coacervates can be widely obtained with high structural stability over 300 days. Being a promising artificial cell model, it shows the special characteristic of compartmentalized encapsulation of substrates, efficiently improving enzymatic interfacial catalytic efficiency of organelle-like communication. Our study holds great potential for advancing the understanding of the structural evolution mechanism of membraneless organelles and provides an instructive technique for constructing multi-compartmental coacervates with long-term stability.
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