Evidence map›Paper›PMID 39971974›Full record

ArticleNPJ Parkinson's disease2025

Motor cortex stimulation ameliorates parkinsonian locomotor deficits: effectual and mechanistic differences from subthalamic modulation.

Lan-Hsin Nancy Lee, Chen Yuan Ngan, Cheng-Kai Yang, Ren-Wei Wang, Hsing-Jung Lai, Chia-Hsiang Chen, Ya-Chin Yang, Chung-Chin Kuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lan-Hsin Nancy LeeDepartment of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-3221-4850
Chen Yuan NganDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Cheng-Kai YangDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ren-Wei WangDepartment of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Hsing-Jung LaiDepartment of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Chia-Hsiang ChenDepartment of Psychiatry, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Ya-Chin YangDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. ycyang@mail.cgu.edu.tw.ORCID http://orcid.org/0000-0002-9983-0607
Chung-Chin KuoDepartment of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan. chungchinkuo@ntu.edu.tw.ORCID http://orcid.org/0000-0001-8208-6829

Funding

Chang Gung Medical Foundation CMRPD1M0811-3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 110-2311-B-182-002-MY3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 110-2320-B-002-012-MY3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 111-2326-B-002-012Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 112-2321-B-001-007Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 112-2321-B-001-012Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 112-2326-B-002-003Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 113-2311-B-182-004-MY3Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 113-2326-B-002-003
6 · The paper itself

Abstract

Subthalamic deep brain stimulation (STN DBS) has been a therapeutic choice for Parkinson's disease (PD). We found that epidural motor cortex stimulation (MCS) with sustained positive (hyperpolarizing) currents could also consistently ameliorate the locomotor deficits in parkinsonian animals, rectifying the pathological paucity in both discharging unit varieties and movement-dependent spatiotemporal activity pattern changes in motor cortex (MC). Mechanistically, MCS hyperpolarizes both glutamatergic pyramidal neurons (PN) and GABAergic interneurons (IN) and consequently partly relieves PN from IN's control. MC discharging units are thus enlarged with enhanced PN burst discharges against a relatively silenced background, presumably compensating for the hypoactive striatal selection to restore the MC activity changes upon movement. Behaviorally, MCS retains interim short pauses like normal locomotor behaviors, in contrast to the propensity of abnormal "restlessness" with STN DBS. Individually designed MCS, alone or in combination with STN DBS and dopaminergic therapy, may provide an optimal therapeutic approach for PD.

Identifiers

PMID39971974
PMCPMC11840011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.