Evidence map›Paper›PMID 39971929›Full record

ReviewNPJ vaccines2025

Product and trial design considerations on the path towards a vaccine to combat opioid overdose.

Asimenia Angelidou, Jacob A Koster, Amy C Sherman, Caitlyn McLoughlin, Pooja Lalwani, Aisling Kelly, Ahsan Saeed, Kerry McEnaney, Lindsey R Baden, Melissa Brogna and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asimenia AngelidouPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6716-6561
Jacob A KosterPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4645-6308
Amy C ShermanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6075-3990
Caitlyn McLoughlinPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0001-6559-8539
Pooja LalwaniPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Aisling KellyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Ahsan SaeedPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Kerry McEnaneyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0378-3456
Lindsey R BadenDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Melissa BrognaDivision of Addiction Medicine, Boston Children's Hospital, Boston, MA, USA.
Elissa R WeitzmanDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Sharon LevyDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
David J DowlingPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1095-6156
Ofer LevyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. ofer.levy@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-5859-1945

Funding

Immunometabolic signatures of BCG-induced neonatal trained immunityK08AI168487 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Asimenia Angelidou · 2023 to 2026
$704k
NIAID NIH HHS 75N93020C00038NIAID NIH HHS K08 AI168487
6 · The paper itself

Abstract

Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials.

Identifiers

PMID39971929
PMCPMC11840009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.