Evidence map›Paper›PMID 39971906›Full record

ArticleNature communications2025

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.

Shubhangi Agarwal, Elizabeth D Kim, Sangyun Lee, Alexander Simon, Alessio Accardi, Crina M Nimigean

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shubhangi AgarwalDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA.
Elizabeth D KimDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA.ORCID http://orcid.org/0000-0002-6240-484X
Sangyun LeeDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA.ORCID http://orcid.org/0000-0001-6272-4678
Alexander SimonDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA.
Alessio AccardiDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA.ORCID http://orcid.org/0000-0002-6584-0102
Crina M NimigeanDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA. crn2002@med.cornell.edu.ORCID http://orcid.org/0000-0002-6254-4447

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Molecular Mechanisms of Potassium Channel Permeation and GatingR01GM088352 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI NIMIGEAN, CRINA M · 2010 to 2025
$5.6M
Atomic basis for chloride channel and transporter gating and selectivityR01GM128420 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ACCARDI, ALESSIO · 2019 to 2022
$1.5M
Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channelsF32GM145091 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIM, ELIZABETH DIONE · 2022 to 2023
$139k
Hartwell Foundation (The Hartwell Foundation) Postdoctoral fellowshipNCI NIH HHS P30 CA016087NIGMS NIH HHS F32 GM145091NIGMS NIH HHS R01 GM088352NIGMS NIH HHS R01 GM128420U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) F32GM145091U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM088352U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM128420
6 · The paper itself

Abstract

BK channels are large-conductance calcium (Ca

Indexed as

Large-Conductance Calcium-Activated Potassium ChannelsCalciumCryoelectron MicroscopyHumansIon Channel GatingMolecular Dynamics SimulationProtein ConformationProtein SubunitsCalciumLarge-Conductance Calcium-Activated Potassium ChannelsProtein Subunits

Identifiers

PMID39971906
PMCPMC11840039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.