Evidence map›Paper›PMID 39971890›Full record

ArticleJournal of cardiovascular translational research2025

Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway.

Neda Tekiyeh Maroof, Saeed Mehrzadi, Maryam Naseroleslami, Nahid Aboutaleb

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Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Neda Tekiyeh MaroofDepartment of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Saeed MehrzadiRazi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Maryam NaseroleslamiDepartment of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. naseroleslami@gmail.com.
Nahid AboutalebPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Aboutaleb.n@iums.ac.ir.ORCID 0000-0002-7514-5939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical application. Using nanocarriers can increase the bioavailability, functionality, and stability of drugs. Current investigation aims to find whether apelin13-loaded nano-niosomes confer cardioprotection in an animal model of myocardial ischemia/reperfusion injury (MI/R) via suppressing ferroptosis, targeting Nrf2 pathway, and AMPK/GSK-3β axis. Ligation of the left anterior coronary artery descending was done to establish the MI/R model and 15 μg/kg of apelin13-loaded nano-niosomes were intramyocardially administrated. Echocardiography, RT-PCR, immunohistochemistry, western blot, ELISA kits, and H&E staining were applied to measure the related indicators. Treatment with both apelin13 and apelin13 loaded nano-niosomes could improve cardiac function and attenuate oxidative stress, myocardial inflammatory factors, and hence ferroptosis by activating the Nrf2 and its downstream proteins HO1, NQO1, AMPK/GSK-3β signaling pathway. In conclusion, apelin13-loaded nano-niosomes are effective MI therapeutic agents against MI/R-induced ferroptosis by activation of Nrf2 via AMPK/GSK-3β axis.

Indexed as

Heme Oxygenase (Decyclizing)Intercellular Signaling Peptides and ProteinsMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacNF-E2-Related Factor 2AMP-Activated Protein KinasesAnimalsDisease Models, AnimalFerroptosisGlycogen Synthase Kinase 3 betaMaleNanoparticlesOxidative StressRatsAMP-Activated Protein Kinasesapelin-13 peptideGlycogen Synthase Kinase 3 betaGsk3b protein, ratHeme Oxygenase (Decyclizing)Hmox1 protein, ratIntercellular Signaling Peptides and ProteinsNfe2l2 protein, ratNF-E2-Related Factor 2Apelin13FerroptosisInflammationMyocardial infarctionNano-niosomesOxidative stress

Identifiers

PMID39971890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.