Evidence map›Paper›PMID 39971836›Full record

ArticleBiochemical genetics2026

ssc-miR-361-3p Suppresses Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Replication and Its In Vivo Expression in Mice.

Qinchuan Zhang, Manyi Zhang, Xiao Qi, Jinliang Sheng, Yanming Sun, Yanbing Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qinchuan ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Manyi ZhangXinjiang Production & Construction Corps Key Laboratory of Animal Biomedicine, Tumushuke, 843900, China.
Xiao QiXinjiang Production & Construction Corps Key Laboratory of Animal Biomedicine, Tumushuke, 843900, China.
Jinliang ShengCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. jinliangsheng@shzu.edu.cn.
Yanming SunCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. sym@shzu.edu.cn.
Yanbing ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. zhangyanbing@shzu.edu.cn.

Funding

Xinjiang Corps Guiding Science and Technology Plan Project 2023ZD042Xinjiang Production & Construction Corps Key Laboratory of Animal Biomedicine FMOF2023002
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the global pig industry. Host microRNAs directly target viral gene regions to exert their disease-fighting effects. PRRS virus (PRRSV) infection upregulates miR-361-3p expression; however, it is unclear whether it can exert inhibitory effects by directly targeting viral genes. Bioinformatic and experimental findings revealed that miR-361-3p inhibited PRRSV replication by directly targeting the PRRSV ORF1b and ORF1a loci. Intramuscular injection of pcDNA3.1-pri-miR-361 verified the expression of miR-361-3p in mammals. In summary, miR-361-3p plays an important role in infection and may be a promising therapeutic target for PRRS, providing insights into possible drug therapies.

Indexed as

Gene Expression Regulation, ViralMicroRNAsPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusVirus ReplicationAnimalsMiceSwineMicroRNAsAntiviralEukaryotic expressionmiRandaPorcine reproductive and respiratory syndrome virusssc-miR-361-3p

Identifiers

PMID39971836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.