ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Neonatal syphilis: clinical and laboratory assessments and postnatal treatments for infants born to infected mothers.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical and trichoscopic features of early congenital syphilis: a single-center cross-sectional study.Frontiers in medicine · 2026Article
- The Resurgence of Syphilis: A 20-Year Evaluation of Epidemiological Trends and Serological Test Performance Using Rapid Plasma Reagin and Indirect Hemagglutination Assays.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
9 authors.
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Abstract
purposeThis study aims to assess congenital syphilis incidence, main clinical presentations and the relation to maternal treatment during pregnancy, with the goal of raising awareness of this emerging public health issue and offering local epidemiological data.
methodsInfants born to mothers diagnosed with syphilis at Etlik City Hospital between June 1, 2023 and June 1, 2024 were included to the study. Patient records were reviewed retrospectively.
resultsDuring the study period, 12,892 live births were recorded, with congenital syphilis detected in 0.12% of cases, corresponding to a rate of 116 cases per 100,000 live births. Fifteen neonates born to mothers with syphilis were evaluated. Penicillin treatment was administered to 93.3% of the neonates, including 73.3% classified as highly probable or probable cases. Bone abnormalities such as periostitis and osteitis were detected in two patients. Only 46.7% of mothers received adequate prenatal treatment, and 40% lacked prenatal care altogether. Co-infections with hepatitis C virus, human papillomavirus, and herpes simplex virus type 2 were noted in 26% of mothers, though none had HIV. Substance addiction was reported in 26.7% of mothers.
conclusionThis study highlights a significant burden of congenital syphilis, with many cases stemming from untreated or inadequately managed maternal infections. Some neonates were infected despite maternal treatment, underscoring gaps in prevention. The limited data from our center, despite high case rates, likely underestimates the regional burden and risks missed diagnoses. These findings emphasize the urgent need for enhanced prenatal screening, timely treatment, and comprehensive care to mitigate congenital syphilis rates.
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