Evidence map›Paper›PMID 39971711›Full record

ArticleJournal of applied clinical medical physics2025

Impact of enhanced leaf model on dose calculation accuracy in single-isocenter multitarget stereotactic radiosurgery treatments.

Hem Moktan, Hongyu Jiang, H Harold Li, Kenny Guida

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hem MoktanDepartment of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas, USA.
Hongyu JiangDepartment of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas, USA.
H Harold LiDepartment of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas, USA.
Kenny GuidaDepartment of Radiation Oncology, University of Kansas Cancer Center, Kansas City, Kansas, USA.ORCID https://orcid.org/0000-0002-2325-9272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSingle-isocenter multitarget (SIMT) radiosurgery has become increasingly popular as advancement in planning and delivery systems have made this approach clinically viable. With targets varying in size and distance from isocenter, SIMT plans are highly complex with dynamic multileaf collimator (MLC) motion. Our department recently commissioned Eclipse Treatment Planning System v18.0, which included a novel enhanced leaf model (ELM) for photon dose calculation. ELM represents the biggest update in MLC modeling on a commercial treatment planning system over the past decade, yielding improvements in leaf modeling and ray tracing. Considering its dependence on dynamic MLC movements, we set out to assess the potential clinical impact of ELM on SIMT.

methodsDynamic zebra crosswalk (DZC) plans were delivered on a Varian Edge to investigate ELM. DZCs consisted of sweeping MLC gaps (ranging 1-15 mm) across a 3 cm width at isocenter, 4 cm, 8 cm, and 12 cm along the x-axis. Phantom dose calculations were performed using AAA v15.6 and v18.0 (with ELM) for 6 MV flattening filter free DZC plans and compared to measurements using stereotactic radiosurgery MapCHECK (Sun Nuclear Corporation) and Gafchromic EBT4 films (Ashland). To assess potential impact on SIMT, ten patients were retrospectively planned with RapidArc and HyperArc. Both versions of AAA were used for dose calculation.

resultsDZC measurements showed improved agreement with ELM; differences between measured and calculated doses were reduced by as much as 19% for the smallest sweeping gaps at off-axis distances. Differences in central profile dose for DZCs increased with reduced gap size and increased off-axis position. SIMT plans showed up to 4.0% increase in planning target volume (PTV) maximum dose when switching from AAA v15.6 to v18.0.

conclusionDose calculations with ELM mirrored diode and film measurements for highly modulated SIMT plans. ELM represents a major improvement in MLC modeling that more accurately reflects current treatment delivery practice.

Indexed as

NeoplasmsPhantoms, ImagingRadiosurgeryRadiotherapy Planning, Computer-AssistedAlgorithmsHumansOrgans at RiskParticle AcceleratorsRadiotherapy DosageRadiotherapy, Intensity-Modulatedenhanced leaf modelMLC modelingtreatment planningVarian Eclipse v18.0

Identifiers

PMID39971711
PMCPMC12148782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.