Trial reportInternational dental journal2025
Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial.
Trial report in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- Eggshell-derived hydroxyapatite as a bioactive filler for toothpaste: rheology and enamel remineralization performance.Odontology · 2026Article
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Cytotoxicity and Genotoxicity of Fluoride Toothpastes in Buccal Cells.Acta stomatologica Croatica · 2026Article
- Optimization and evaluation of fluoride-functionalized nano-hydroxyapatite derived fromBiology methods & protocols · 2026Article
- Evaluation of the Efficacy of a Dentifrice Tablet to Prevent Dental Caries: A Microbial Study.Dentistry journal · 2025Article
- Color Change and Color Stability of White Spot Lesions Treated with Resin Infiltration, Microabrasion, or Nano-Hydroxyapatite Remineralization: An In Vitro Study.Dentistry journal · 2025Article
- Applications of chitosan in oral health and diseases.Frontiers in oral health · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to evaluate the remineralizing effect of hydroxyapatite and fluoride containing toothpastes (HAF's) on active caries lesions compared to a fluoridated standard toothpaste in pre/schoolchildren. A total of 610 children (4-5 and 6-7 years old) were enrolled. Four toothpastes, 2 containing fluoride-substituted hydroxyapatite (HAF) (1000 and 1450 ppmF) and magnesium-, strontium-, carbonate-substituted hydroxyapatite, in a chitosan matrix and 2 Mono fluoridated toothpastes (NaMFP) (1000 and 1450 ppmF), were randomly administered for 24 months. The children were instructed to brush for 2 minutes 3 times/day. Caries activities, by clinical surface features, were recorded at baseline and 12- and 24-month follow-ups. A per-protocol analysis was adopted, thus excluding children lost to follow-up. Overall, 518 children completed the trial. Baseline comparisons revealed no significant differences in primary teeth caries rates between HAF and NaMFP groups, both for enamel and dentinal lesions. By the end of the study, the HAF group exhibited a statistically significant reduction in enamel lesions compared to the NaMFP group (P < .01). Of the 40 partially active lesions at baseline in the HAF group, 13 were inactive at the 2-year follow-up. Of the active lesions in the HAF group (n = 78) at baseline, nearly 3-quarters (n = 58) were inactive at the follow-up. The difference between the 2 groups (HAF vs NaMFP) in terms of change of status in primary dentition (active at baseline and inactive at follow-up) was statistically significant (P = .04). Regarding dentinal lesions, both groups presented similar percentages of inactive lesions that were filled at the end of follow-up (P = .08). However, the HAF group demonstrated a higher number of inactivated lesions compared to the NaMFP group. The toothpaste containing biomimetic hydroxyapatite and fluoride may be better for children with active caries lesion in primary dentition.
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