Evidence map›Paper›PMID 39971627›Full record

ReviewEuropean journal of haematology2025

Relapsed/Refractory Follicular Lymphoma: Current Advances and Emerging Perspectives.

Giulio Caridà, Enrica Antonia Martino, Antonella Bruzzese, Daniele Caracciolo, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Teresa Rossi, Antonino Neri and 5 more

Abstract readReview
In one paragraph

Review in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giulio CaridàHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Enrica Antonia MartinoHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Antonella BruzzeseHematology Unit, Department of Onco-Hematology, Cosenza, Italy.ORCID https://orcid.org/0000-0002-9456-2404
Daniele CaraccioloDepartment of Experimental and Clinical Medicine, University of Catanzaro, Catanzaro, Italy.
Caterina LabancaHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Francesco MendicinoHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Eugenio LuciaHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Virginia OlivitoHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Teresa RossiLaboratory of Translational Research Azienda USL-IRCSS di Reggio Emilia, Reggio Emilia, Italy.
Antonino NeriScientific Directorate, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Ernesto VignaHematology Unit, Department of Onco-Hematology, Cosenza, Italy.
Pierfrancesco TassoneDepartment of Experimental and Clinical Medicine, University of Catanzaro, Catanzaro, Italy.
Pierosandro TagliaferriDepartment of Experimental and Clinical Medicine, University of Catanzaro, Catanzaro, Italy.
Fortunato MorabitoGruppo Amici Dell'Ematologia Foundation-GrADE, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0002-2585-7073
Massimo GentileHematology Unit, Department of Onco-Hematology, Cosenza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma (FL) is a prevalent indolent non-Hodgkin lymphoma (NHL) characterized by a relapsing course and eventual refractoriness to therapy. Despite advancements in treatment, FL remains incurable, necessitating ongoing research into novel therapeutic strategies. This review provides a comprehensive overview of current standard treatments for relapsed or refractory (R/R) FL, including chemoimmunotherapy and stem cell transplantation, and delves into emerging therapies such as chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies. We discuss the efficacy and safety profiles of these innovative treatments, their integration into existing treatment paradigms, and the potential they hold in altering the natural history of FL. Additionally, we explore the challenges associated with these therapies, including accessibility, cost, and long-term management of adverse effects. By examining the evolving therapeutic landscape, this review aims to provide insights into future directions for achieving sustained remission and improving the quality of life in patients with R/R FL.

Indexed as

Lymphoma, FollicularCombined Modality TherapyDisease ManagementDrug Resistance, NeoplasmHumansImmunotherapy, AdoptiveRecurrenceTreatment Outcomebispecific antibodiesCAR‐TR/R FLtherapy

Identifiers

PMID39971627
PMCPMC11976689

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.