Observational studyBMJ open2025
Quantitative CT imaging characteristics of patients with chronic obstructive pulmonary disease with different eosinophil levels: a retrospective observational study using linked data from a tertiary hospital in China.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Airway Response to Dual Bronchodilation and Its Association with Inflammatory Markers in Treatment-Naïve Chronic Obstructive Pulmonary Disease: A Quantitative Computed Tomography Study.Life (Basel, Switzerland) · 2026Article
- Moderate and Severe Exacerbations and Healthcare Resource Utilization in Chinese Patients with COPD on Triple Therapy: A Retrospective Database Study.Advances in therapy · 2026Article
- Relationship between quantitative CT and cardiac function in patients with severe COPD exacerbations (ECOPD).BMJ open respiratory research · 2026Article
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Authors and funding
7 authors.
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Abstract
objectiveTo investigate the relationship between eosinophil (EOS) and CT imaging, we quantitatively evaluated the bronchial wall thickening, emphysema index (EI) and pulmonary vascular parameters in patients with chronic obstructive pulmonary disease (COPD) based on different EOS levels.
designRetrospective observational study.
settingA tertiary hospital in China.
participants448 patients with COPD from January 2020 to January 2023.
main outcome measuresLaboratory data, chest CT and pulmonary function based on different EOS levels: <150/µL, ≥150/µL; <100/µL, 100-300/µL, ≥300/µL; <2%, ≥2%.
resultsWe evaluated the records of 448 patients diagnosed with COPD. The prevalence of eosinophilia with EOS ≥2% was 41.1% (184 cases), 33.7% (151 cases) with EOS ≥150/µL and 9.4% (42 cases) with EOS ≥300/µL. A lower EOS (EOS <2% or EOS <150/µL) was associated with chronic pulmonary heart disease. The neutrophil count and percentage were significantly higher in the relatively lower EOS group (EOS <2%, EOS <150/µL or EOS <100/µL). When the groups were divided based on the two cut-off values of 2% of EOS percentage and 150/µL of absolute EOS value, no statistical significance was observed for the entire lung, left lung, right lung, lung lobe volume, lung index (EI), and lung emphysema heterogeneity index (HI). However, compared with the 100-300/µL group, the EI of the right upper lobe of the lung was lower in the EOS ≥300/µL group (0.32 vs 0.37, p<0.05). Airway wall thickness, wall area percentage and Pi10 in the EOS ≥2%, EOS ≥150/µL and 100-300/µL groups were lower than those in the EOS <2%, EOS <150/µL and EOS <100/µL groups, respectively. Compared with the EOS <100/µL group, Pi10 in the EOS ≥300/µL group was lower. According to the different cut-off values, such as percentage and absolute value of EOS, there was no significant difference in pulmonary vascular parameters, such as in cross-sectional area less than 5 mm
conclusionsHypereosinophilic COPD (EOS ≥2% or EOS ≥150/µL or EOS ≥300/µL) appears to have less bronchial thickening and better lung function. Notably, in patients with EOS ≥300/µL, the EI of the right upper lobe is reduced. These findings provide valuable insights into the role of EOS in COPD pathophysiology.
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