Trial reportBMJ mental health2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial.
Trial report in BMJ mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03183388 (Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Who cites it
4 citing papers in PubMed.
- Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series.Frontiers in child and adolescent psychiatry · 2026Article
- Advancing Research on Suicide and Mental Health in Autistic Adults Through a Research Domain Criteria (RDoC)-Inspired Framework.Autism in adulthood · 2025Article
- Bipolar disorder.Lancet (London, England) · 2025Review
- Circadian rhythms and mental health.BMJ mental health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundMood episodes and high suicide risk of bipolar disorder (BD) are thought to derive from amygdala-ventral prefrontal cortex emotion regulation brain circuitry dysfunction and resulting emotion dysregulation, making these potential intervention targets.
objectiveTo assess feasibility, acceptability, and preliminary efficacy in engaging the emotion regulation targets of two Brain Emotion Circuitry-targeted Self-Monitoring and Regulation Therapy (BE-SMART) variations in adolescents and young adults with BD (BD
methodsIn a single-blind, parallel, pilot-randomised trial, 60 BD
findingsIn addition to demonstrating feasibility, only BE-SMART-DR showed pre-treatment to post-treatment improvements in DR regularity (Cohen's
conclusionsRegularising DRs may enhance emotion regulation brain circuitry functioning, emotion regulation, and reduce suicide risk in BD CLINICAL IMPLICATIONS: Chronotherapeutic interventions regularising DRs, such as SRT, should be studied further as potential treatment strategies for BD TRIAL REGISTRATION NUMBER: NCT03183388.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.