Evidence map›Paper›PMID 39971587›Full record

ArticleBMJ open gastroenterology2025

Burden of five major types of gastrointestinal cancer in the Eastern Mediterranean Region.

Saleh A Alessy, Eileen Morgan, Ali S Al-Zahrani, Mariam Zahwe, Heba Fouad, Freddie Bray, Ariana Znaor, Saleh A Alqahtani

Abstract read
In one paragraph

Article in BMJ open gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Unmasking hidden trends: subsite-specific mortality patterns in colorectal and anal cancers in Spain, 1999-2023.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saleh A AlessyDepartment of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia salessy@kfshrc.edu.sa.ORCID http://orcid.org/0000-0003-4588-7410
Eileen MorganCancer Surveillance Branch, The International Agency for Research on Cancer, Lyon, France.
Ali S Al-ZahraniResearch and Innovations, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Mariam ZahweCancer Surveillance Branch, The International Agency for Research on Cancer, Lyon, France.
Heba FouadDepartment of Noncommunicable Diseases and Mental Health, World Health Organisation Regional Office for the Eastern Mediterranean, Cairo, Egypt.
Freddie BrayCancer Surveillance Branch, The International Agency for Research on Cancer, Lyon, France.
Ariana ZnaorCancer Surveillance Branch, The International Agency for Research on Cancer, Lyon, France.
Saleh A AlqahtaniLiver, Digestive, and Lifestyle Health Research Section, and Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Funding

World Health Organization 001
6 · The paper itself

Abstract

objectiveWe provide an overview of the latest estimates of five gastrointestinal (GI) cancers in the Eastern Mediterranean Region (EMR) countries to guide cancer control policy.

methodsWe extracted the number of cases and deaths for oesophageal, gastric, liver, colorectal and pancreatic cancers from the GLOBOCAN database produced as estimated by the International Agency for Research on Cancer for the year 2022. Age-standardised incidence and mortality rates (ASR) per 100 000 person-years were estimated for the 22 EMR countries, cancer site and sex.

resultsThe estimated 173 000 new cancer cases and 139 000 deaths from the five GI cancers corresponded to 22.2% of the incidence and 28.7% of the mortality burden in the EMR. Across all cancers (for both sexes combined), colorectal cancer ranked third (6.9%; ASR 8.9), followed by liver cancer (6.2%; ASR 8.4) in terms of incidence, while liver cancer (9.6%; ASR 8.1) and gastric cancer (6.4%; ASR 5.5) were the third and fourth leading causes of cancer-related mortality in the region, respectively. Marked differences in cancer incidence and mortality rates were observed between the 22 countries, particularly the 10-fold variations seen in liver cancer incidence.

conclusionGI cancers currently account for an important fraction of the cancer burden in the EMR; the present analysis seeks to inform tailored decision-making according to the country-specific GI cancer profiles.

Indexed as

Gastrointestinal NeoplasmsLiver NeoplasmsAgedColorectal NeoplasmsCost of IllnessEsophageal NeoplasmsFemaleHumansIncidenceMaleMediterranean RegionMiddle AgedPancreatic NeoplasmsStomach NeoplasmsCANCERCOLORECTAL CANCEREPIDEMIOLOGYGASTROINTESTINAL CANCER

Identifiers

PMID39971587
PMCPMC11840892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.