Evidence map›Paper›PMID 39971300›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Hypercalcemia with the Oral Administration of Active Vitamin D3 and Chinese Herbal Medicine.

Natsuki Matsumoto, Miku Otomaru, Kumiko Asai, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natsuki MatsumotoDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Miku OtomaruDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Kumiko AsaiDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Kenji HaraDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Takafumi TsuchiyaDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Kohzo TakebayashiDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.
Koshi HashimotoDepartment of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causes of hypercalcemia vary. There are high-calcium-containing preparations in Chinese herbal medicine, which may contribute to drug-induced hypercalcemia. We encountered a case of hypercalcemia following the simultaneous administration of an active vitamin D3 preparation and several Chinese herbal medicines. The patient had been treated at several medical institutions, with one institution administering eldecalcitol and another institution administering Keishikaryukotsuboreito, Borei powder, and Goreisan. The patient presented with drug-induced hypercalcemia due to an unexpected synergistic effect. Confirmation of prescriptions for patients with multiple medical visits and recognition of the components and side effects of Chinese herbal medicines is thus considered to be extremely important.

Indexed as

CholecalciferolDrugs, Chinese HerbalHypercalcemiaAdministration, OralHumansCholecalciferolDrugs, Chinese Herbalactive vitamin D3Chinese herbal medicinehypercalcemiapolypharmacy

Identifiers

PMID39971300
PMCPMC12425583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.