Evidence map›Paper›PMID 39971289›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Multimodal Treatment Approach for Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Gallbladder: A Patient with a Favorable Survival Outcome.

Shinji Oe, Koichi Nakamura, Nobuhiko Shinohara, Daiki Uchihara, Koichiro Miyagawa, Teppei Tsukamoto, Yasuhisa Mori, Masaru Harada

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shinji OeThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Koichi NakamuraThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Nobuhiko ShinoharaThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Daiki UchiharaThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Koichiro MiyagawaThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Teppei TsukamotoDepartment of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Japan.
Yasuhisa MoriDepartment of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Japan.
Masaru HaradaThird Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder (GB-MiNEN) is an exceptionally rare and aggressive tumor with no established treatment guidelines. We herein present the case of a 53-year-old woman with GB-MiNEN who was treated with irinotecan and cisplatin therapy, which led to a significant tumor reduction and subsequent conversion surgery. Despite a later recurrence, multimodal therapy extended survival for over two and a half years. This case underscores the potential benefit of conversion surgery combined with systemic chemotherapy, thus suggesting that multimodal treatment may improve the outcomes of GB-MiNEN. Our findings highlight the need for further studies to optimize the treatment strategies for this rare malignancy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsGallbladderGallbladder NeoplasmsNeoplasms, Complex and MixedNeuroendocrine TumorsBiomarkers, TumorChemotherapy, AdjuvantCholecystectomyCisplatinFemaleHumansIrinotecanMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalTime FactorsBiomarkers, TumorCisplatinIrinotecanmixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN)neuroendocrine carcinoma (NEC)neuroendocrine neoplasm (NEN)

Identifiers

PMID39971289
PMCPMC12425567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.