ArticleJournal of pain and symptom management2025
Study of Complementary and Integrative Interventions in Pediatric Patients With Serious Illness.
Article in Journal of pain and symptom management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meridian-based traditional Chinese medicine interventions for supportive care in children, adolescents, and young adults with cancer: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Integrative and Complementary Interventions Result in Significant Positive Effect Sizes in Quality of Life and Symptom Burden among Patients with Pediatric Cancer and Other Serious Illness.Research square · 2025Article
- Development of the Intervention Protocol for the Study of Creative Arts Among Children With Cancer.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
contextPediatric patients report using complementary and integrative health interventions (CHI) for symptom management.
objectiveFeasibility and initial effect sizes of CHI with patients at two children's hospitals.
methodsUsing convenience sampling at two academic centers and accepting the wide age range of patients traditionally treated in children's hospitals, we examined feasibility of CHI and outcomes of quality of life (QOL) and symptoms with validated surveys and two physiologic measures. A priori feasibility thresholds were 90% accrual rate and 60% completion of at least two surveys and one CHI session.
resultsOver 18 months we accrued 100 participants (Site 1, n = 34; Site 2, n = 66) who completed 811 assessments. Participants were aged 2-29 years (M = 13.5, SD = 5.6), 65% female, 23% from underrepresented populations, 52% with cancer versus other serious illness. Accrual rate was 94%, completion rate was 87%, acceptability was 96%. Ninety-nine participants received 191 total CHI sessions: acupuncture (39%), aromatherapy (35%), creative arts (20%), massage therapy (5%) and hypnosis (1%). After CHI heart rate decreased and symptom scores improved for anxiety, fatigue, nausea, pain, and sadness (Cohen's d effect sizes 0.22-0.99). Adjusted mixed-effects models suggested that the Faces Scale scores improved over time (b = -0.19, P < 0.01).
conclusionProspective two-site data collection in relationship to CHI exceeded feasibility thresholds and was acceptable. When given the choice, CHI were popular and may have contributed to improved QOL immediately and longitudinally. These preliminary findings support further study of CHI for targeted symptoms in distinct populations with rigor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.