ArticleRespiratory physiology & neurobiology2025
Bulk and regional diaphragm blood flow during chemical hyperpnea in pulmonary hypertensive rats.
Article in Respiratory physiology & neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary hypertension (PH) is a disease characterized by increased pulmonary arterial pressures, impaired gas exchange, dyspnea, and diaphragmatic dysfunction. Specifically, in PH, the diaphragm displays impaired contractility, vascular dysfunction, and blood flow redistribution toward less mechanically advantageous regions such as the ventral costal and crural diaphragm at rest and during submaximal exercise. While diaphragm blood flow is not a limitation to maximal exercise in health, whether it limits diaphragm function in PH is unknown. We hypothesized that, during chemically induced hyperpnea: 1) diaphragm blood flow will be lower in rats with PH compared with healthy controls due to vasodilatory impairments in the diaphragm vasculature, and 2) in PH, blood flow will be redistributed toward less mechanically advantageous regions of the diaphragm. Female Sprague-Dawley rats were randomized into healthy (n = 12) or monocrotaline-induced PH (n = 12) groups. Fluorescent microspheres were used to determine bulk and regional diaphragm blood flow at rest and during hypoxic-hypercapnic gas inhalation (10 % O
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