ArticleNephrology (Carlton, Vic.)2025
Kidney Function and Size in Children With Down Syndrome: A Cross-Sectional Study.
Article in Nephrology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Age- and sex-specific serum creatinine reference curves in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Serum Creatinine Levels in Children With Down Syndrome: A Single-Centre Retrospective Study in Ireland.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Rethinking Creatinine in Children With Down Syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Protecting Kidney Health in the First 1000 Days: The Pediatrician's Role in Safeguarding the Weakest.Diseases (Basel, Switzerland) · 2026Review
- Cochlear Implantation in Down Syndrome: Functional Outcomes, Challenges, and Management Strategies.Audiology research · 2026Review
- Etiology and longitudinal kidney outcomes in children with nephrocalcinosis: a retrospective cohort study.Frontiers in pediatrics · 2026Article
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Authors and funding
9 authors.
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Abstract
Down syndrome (DS) is associated with a high prevalence of congenital heart, gastrointestinal, and endocrine anomalies, as well as a heightened risk for kidney and urinary tract abnormalities. The renal anomalies occur in up to 3.2% of DS cases at birth-four to five times higher than in the general population. Despite this, current DS management guidelines lack routine kidney evaluations, even though risk factors like neonatal acute kidney injury, renal hypoplasia and obesity may predispose DS children to chronic kidney disease (CKD). In a cross-sectional study, we analysed kidney size and function in 54 DS children. Results revealed that 25% of patients exhibited renal hypoplasia, 26% had an estimated glomerular filtration rate (eGFR) below 90 mL/min/1.73 m
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