Evidence map›Paper›PMID 39970875›Full record

Trial reportCell reports. Medicine2025

Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial.

Alessandro Micarelli, Simona Mrakic-Sposta, Alessandra Vezzoli, Sandro Malacrida, Sara Caputo, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Ilaria Iennaco, Ivan Granito and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04529161 (Changes in Olfactory and Taste Behavior in Overweight / Obese Subjects Undergoing Fasting Mimicking Diet), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04529161 nacompletednot on this map

Changes in Olfactory and Taste Behavior in Overweight / Obese Subjects Undergoing Fasting Mimicking Diet (FMD)

TypeinterventionalSponsorUniter OnlusRan2020 to 2022Enrolled102ConditionsDiet, Healthy, Obesity, Olfaction DisordersArmsFasting Mimicking Diet (FMD), Routinary diet habits
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandro MicarelliUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy. Electronic address: alessandromicarelli@yahoo.it.
Simona Mrakic-SpostaInstitute of Clinical Physiology, National Research Council (CNR), Milan, Italy.
Alessandra VezzoliInstitute of Clinical Physiology, National Research Council (CNR), Milan, Italy.
Sandro MalacridaInstitute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy.
Sara CaputoEuropean Longevity Institute, Milan, Italy.
Beatrice MicarelliUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy.
Ilaria MisiciUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy.
Valentina CarbiniUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy.
Ilaria IennacoUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy.
Ivan GranitoUnit of Neuroscience, Rehabilitation and Sensory Organs, UNITER ONLUS, Rome, Italy.
Valter D LongoLongevity Institute, Leonard Davis School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. Electronic address: vlongo@usc.edu.
Marco AlessandriniUniversity of Rome Tor Vergata - Department of Clinical Sciences and Translational Medicine - Ear-Nose-Throat Unit, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is associated with a decrease in chemosensory perception acuity and increased disease risk, pointing to the need for feasible interventions that affect smell, taste, and cardiometabolic markers. Here, subjects with overweight/obesity are treated with six monthly cycles of a fasting-mimicking diet (FMD) lasting 5 days followed by a normal diet for the rest of the month to determine their effects on chemosensory function and cardiometabolic risk factors. Both arms of the 102 randomized cross-over trial participants indicate FMD-dependent improvements in a wide range of taste and smell chemosensory functions. The portion of hyposmic subjects is reduced from 38.1% at baseline to 6.4% at the end of 6 FMD cycles. FMD cycles also reduce cardiometabolic and inflammatory markers and drug use in diabetic patients. This trial provides evidence for the effect of periodic FMD cycles in improving chemosensory function while reducing cardiometabolic risk factors without requiring long-term lifestyle changes. The trial is registered at ClinicalTrials.gov (NCT04529161).

Indexed as

DietFastingObesityAdultCross-Over StudiesFemaleHumansMaleMiddle AgedOverweightSmellTastefasting-mimicking dietghrelinleptinobesitysmelltaste

Identifiers

PMID39970875
PMCPMC11866515

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.