Evidence map›Paper›PMID 39970612›Full record

ArticleHearing research2025

A mutation in Tmem135 causes progressive sensorineural hearing loss.

Mi-Jung Kim, Shion Simms, Ghazaleh Behnammanesh, Wei-Wen Chen, Yohei Honkura, Jun Suzuki, Hyo-Jin Park, Marcus Milani, Yukio Katori, Jonathan E Bird and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Limited Potential to Reverse Deafness Caused by Mutation of Myo7a.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mi-Jung KimDepartment of Physiology and Aging, University of Florida, Gainesville, FL, United States.
Shion SimmsDepartment of Physiology and Aging, University of Florida, Gainesville, FL, United States.
Ghazaleh BehnammaneshDepartment of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, United States.
Wei-Wen ChenSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States.
Yohei HonkuraDepartment of Otolaryngology-Head &Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Jun SuzukiDepartment of Otolaryngology-Head &Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hyo-Jin ParkDepartment of Physiology and Aging, University of Florida, Gainesville, FL, United States.
Marcus MilaniDepartment of Physiology and Aging, University of Florida, Gainesville, FL, United States.
Yukio KatoriDepartment of Otolaryngology-Head &Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Jonathan E BirdDepartment of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, United States.
Akihiro IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, WI, United States.
Shinichi SomeyaDepartment of Physiology and Aging, University of Florida, Gainesville, FL, United States; Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL, United States. Electronic address: someya@ufl.edu.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Molecular Genetics of Age-Dependent Retinal DegenerationR01EY022086 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2012 to 2026
$6.1M
Molecular Mechanisms of Hair Bundle Development and MaintenanceR01DC018827 · NIDCD · UNIVERSITY OF FLORIDA · PI Jonathan Edward Bird · 2020 to 2026
$3.0M
Cochlear Detoxification SystemR01DC014437 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2015 to 2019
$2.2M
Mitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing LossR01DC012552 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2013 to 2017
$1.9M
The Role of Glutathione Reductase in Age-related Hearing LossR03DC011840 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2011 to 2013
$432k
NEI NIH HHS R01 EY022086NIA NIH HHS P30 AG028740NIDCD NIH HHS R01 DC012552NIDCD NIH HHS R01 DC014437NIDCD NIH HHS R01 DC018827NIDCD NIH HHS R03 DC011840
6 · The paper itself

Abstract

Transmembrane protein 135 (TMEM135) is a highly conserved 52 kDa protein with five predicted transmembrane domains that colocalizes with mitochondria and peroxisomes. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism across multiple tissues and species; however, its role in the inner ear and auditory system remains unknown. We investigated the function of TMEM135 in hearing using wild-type (WT) and Tmem135

Indexed as

CochleaHearingHearing Loss, SensorineuralMembrane ProteinsMutationAnimalsAuditory ThresholdDisease Models, AnimalDisease ProgressionEvoked Potentials, Auditory, Brain StemGenetic Predisposition to DiseaseHair Cells, Auditory, InnerHair Cells, Auditory, OuterMaleMiceMice, Inbred CBAMembrane ProteinsAgingCochleaHair cellHearing lossMitochondriaMitochondrial dynamicsTMEM135

Identifiers

PMID39970612
PMCPMC12171014

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.