Evidence map›Paper›PMID 39970575›Full record

ArticleDrug and alcohol dependence2025

The association between cannabis and alcohol co-use and momentary subjective effects: Risks for increasingly hazardous cannabis use.

Margaret F Bedillion, Emily B Ansell

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Margaret F BedillionThe Pennsylvania State University, University Park, PA, USA. Electronic address: margaret.bedillion@nyspi.columbia.edu.
Emily B AnsellThe Pennsylvania State University, University Park, PA, USA.

Funding

Translational Clinical Research Fellowship on Substance Use DisordersT32DA007294 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Frances Rudnick Levin, Diana M Martinez · 1993 to 2026
$9.3M
Neurobehavioral Effects of Frequent Co-use of Alcohol and CannabisR01DA056137 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI EMILY B ANSELL, Eric D Claus · 2023 to 2026
$2.8M
Ecological Momentary Assessment of Cannabis Use Effects in Young AdultsR01DA039924 · NIDA · YALE UNIVERSITY · PI ANSELL, EMILY B · 2016 to 2020
$2.3M
Effects of Alcohol and Tobacco Co-use on Momentary Subjective Cannabis Effects: Risks for Increasingly Hazardous Cannabis UseF31DA056066 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI BEDILLION, MARGARET · 2022 to 2023
$91k
NIDA NIH HHS F31 DA056066NIDA NIH HHS R01 DA039924NIDA NIH HHS R01 DA056137NIDA NIH HHS T32 DA007294
6 · The paper itself

Abstract

backgroundCo-use of cannabis and alcohol is associated with a higher prevalence of health-related, psychiatric, and psychosocial impairments. The aims of this study were to 1) examine the association between cannabis and alcohol co-use and subjective effects, 2) determine whether the time between cannabis and alcohol use is associated with subjective effects, and 3) examine whether subjective responses to co-use are associated with hazardous cannabis use over time.

methodsYoung adults who co-used cannabis and alcohol (N = 155, 55.5 % women, Mean age=21 yo) completed baseline, six-month, and twelve-month assessments of hazardous cannabis use. Co-use and subjective effects were assessed across 21 days of EMA at baseline.

findingsCo-use was associated with greater momentary subjective intoxication, compared to cannabis- and alcohol-only, and stimulation and bad effects, compared to cannabis-only. Subjective intoxication was significantly higher for co-use within 0-90minutes compared to cannabis-only. Subjective intoxication was significantly higher for co-use within 0-120minutes compared to alcohol-only. Co-use within 0-30minutes was associated with significantly greater stimulation and bad effects, compared to cannabis-only use moments. The extent to which an individual becomes more intoxicated when co-using the greater the risk the individual had for increasing hazardous cannabis use six and twelve months later.

conclusionFindings indicate that co-use is associated with increased intoxication, compared to cannabis or alcohol use alone, and increased stimulation and bad effects, compared to cannabis use alone. Subjective responses to co-use in a naturalistic setting are important to consider when evaluating long-term risk of cannabis use among young adults.

Indexed as

Alcohol DrinkingMarijuana SmokingMarijuana UseAdolescentAdultEcological Momentary AssessmentFemaleHumansMaleRisk FactorsYoung AdultAlcoholCannabisCo-useSAMSubjective effects

Identifiers

PMID39970575
PMCPMC11890099

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.