ArticleScience translational medicine2025
Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model.
Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07488988 (SCARFREE-001), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SCARFREE-001: A Phase 2 Dose-Finding and Proof-of-Concept Study of Intradermal Verteporfin for Scar Prevention in Open and Closed Surgical Wounds
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From mechanics to mobilization: a biomechanically-informed rehabilitation framework for cesarean-related scars.BMC women's health · 2026Pooled it
- Nanozyme-crosslinked dual-network hydrogel enables multi-stage modulation of the dysregulated repair cascade for regenerative wound healing.Bioactive materials · 2026Article
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Mechanical, Redox, and Bioelectrical Coupling in Hydrogels for Cutaneous Regeneration: Network Design and Structure-Property Relationships.Gels (Basel, Switzerland) · 2026Review
- A human ex vivo model of radiation-induced skin injury recapitulates p53-driven profibrotic response to radiotherapy.JCI insight · 2026Article
- A photocuring double-network hydrogel enhances mechanotransduction and scavenges ROS to accelerate pressure injury healing.Materials today. Bio · 2026Article
- Imageomics defines granular morphological changes of human skin with age and reveals a rejuvenating effect of xenografting.bioRxiv : the preprint server for biology · 2026Article
- Interleukin-10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways.Cell proliferation · 2026Article
- Anisotropic mechanotransductive tissue constructsBioactive materials · 2026Article
- Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerative Healing.Biology · 2026Review
- Approaching Scarless Wound Healing: From Passive Anti-Fibrotic to Proactive and Programmable Pro-Regenerative Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses.Cell reports · 2026Article
- Spatiotemporal dynamics of mammalian wound healing.Cell discovery · 2026Review
- Gene expression dynamics in wound healing: Comparative analysis between the wound edge and center.PloS one · 2026Article
- Cu-CeOFrontiers in bioengineering and biotechnology · 2026Article
- Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.Results and problems in cell differentiation · 2026Review
- Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing.Biological procedures online · 2025Article
- Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin.Cell stem cell · 2025Article
- Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics.MedComm · 2025Review
- Recent advances on Hippo-YAP pathway in skin diseases.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
34 authors.
Funding
Abstract
Modulating mechanotransduction by inhibiting yes-associated protein (YAP) in mice yields wound regeneration without scarring. However, rodents are loose-skinned and fail to recapitulate key aspects of human wound repair. We sought to elucidate the effects of YAP inhibition in red Duroc pig wounds, the most human-like model of scarring. We show that one-time treatment with verteporfin, a YAP inhibitor, immediately after wounding is sufficient to prevent scarring and to drive wound regeneration in pigs. By performing single-cell RNA sequencing (scRNA-seq) on porcine wounds in conjunction with spatial proteomic analysis, we found perturbations in fibroblast dynamics with verteporfin treatment and the presence of putative pro-regenerative/profibrotic fibroblasts enriched in regenerating/scarring pig wounds, respectively. We also identified differences in enriched myeloid cell subpopulations after treatment and linked this observation to increased elaboration of interleukin-33 (IL-33) in regenerating wounds. Finally, we validated our findings in a xenograft wound model containing human neonatal foreskin engrafted onto nude mice and used scRNA-seq of human wound cells to draw parallels with fibroblast subpopulation dynamics in porcine wounds. Collectively, our findings provide support for the clinical translation of local mechanotransduction inhibitors to prevent human skin scarring, and they clarify a YAP/IL-33 signaling axis in large animal wound regeneration.
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Registered trials
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