Evidence map›Paper›PMID 39970178›Full record

ArticlePLoS biology2025

Neural development goes retro: Gags as essential modulators of synapse formation.

Yung-Heng Chang, Josh Dubnau

Abstract readComment
In one paragraph

Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yung-Heng ChangDepartment of Anesthesiology, Stony Brook School of Medicine, Stony Brook, New York, United States of America.
Josh DubnauDepartment of Anesthesiology, Stony Brook School of Medicine, Stony Brook, New York, United States of America.ORCID https://orcid.org/0000-0002-9285-7444

Funding

Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementiasR01AG078788 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI JOSHUA T DUBNAU · 2022 to 2026
$3.8M
Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retrovirusesRF1AG076493 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DUBNAU, JOSHUA T · 2022 to 2022
$1.8M
Circuit level analysis of sleep-metabolism interactionsR01NS131628 · NINDS · TEXAS A&M UNIVERSITY · PI JOSHUA T DUBNAU, Alex C Keene · 2024 to 2026
$1.2M
NIA NIH HHS R01 AG078788NIA NIH HHS RF1 AG076493NINDS NIH HHS R01 NS131628
6 · The paper itself

Abstract

Neurodevelopment requires dynamic control of synapse number. A new study in PLOS Biology reveals that the gag protein of Copia, an active retrotransposon, forms virus-like capsids that transfer its own RNA across the Drosophila neuromuscular junction. Here, Copia acts antagonistically with Arc, another retrotransposon gag protein, to regulate synapse formation.

Indexed as

Drosophila ProteinsGene Products, gagNeurogenesisRetroelementsSynapsesAnimalsDrosophilaDrosophila melanogasterNeuromuscular JunctionDrosophila ProteinsGene Products, gagRetroelements

Identifiers

PMID39970178
PMCPMC11838888

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.