Evidence map›Paper›PMID 39970150›Full record

ArticlePloS one2025

SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes.

Pandora L Wander, Elliott Lowy, Anna Korpak, Lauren A Beste, Steven E Kahn, Edward J Boyko

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pandora L WanderVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.ORCID 0000-0003-3671-1464
Elliott LowyVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.
Anna KorpakVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.
Lauren A BesteVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.ORCID 0000-0001-6488-435X
Steven E KahnVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.ORCID 0000-0001-7307-9002
Edward J BoykoVeterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the impact of SARS-CoV-2 on long-term glycemia. RESEARCH DESIGN AND

methodsWe conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020-May 31, 2022) among individuals with ≥ 1 positive nasal swab for SARS-CoV-2 and individuals with ≥ 1 laboratory test of any type but no positive swab. Two incident diabetes cohorts were defined based on: 1) a computable phenotype using a combination of diagnosis codes, laboratory tests, and receipt of glucose-lowering medications (n = 17,754); and 2) the presence of ≥ 2 HbA1c results ≥ 6.5% (n = 4,768). We fit log-binomial models examining associations of SARS-CoV-2 with diabetes remission, defined as ≥ 2 HbA1c measurements < 6.5% ≥ 90 days apart after cessation of any glucose-lowering medications. To help equalize laboratory surveillance of glycemia, we conducted a subgroup analysis among non-hospitalized participants.

resultsIn cohorts 1 and 2 respectively, 25% and 29% had ≥ 1 positive test for SARS-CoV-2 prior to enrollment, and 21% and 11% had remission. SARS-CoV-2 was associated with a higher chance of remission by both definitions (1: RR 1.22 [95%CI 1.14-1.29]; 2: RR 1.27 [95%CI 1.07-1.50]) over an average 503 (±202) and 494 (±184) days. The association was attenuated among non-hospitalized participants (1: RR 1.11 [1.04-1.20]; 2: R: 1.17 [95%CI 0.97-1.42]).

conclusionsDiabetes remission was more common in Veterans with new-onset diabetes after SARS-CoV-2. In non-hospitalized participants, who were likely to have more similar laboratory surveillance, the association was diminished. Differences in surveillance or transient hyperglycemia may explain the observed association.

Indexed as

COVID-19Diabetes MellitusVeteransAdultAgedFemaleGlycated HemoglobinHumansIncidenceMaleMiddle AgedRemission InductionRetrospective StudiesSARS-CoV-2United StatesGlycated Hemoglobin

Identifiers

PMID39970150
PMCPMC11838867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.