Evidence map›Paper›PMID 39969994›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria.

Justin M Di Trani, Jiacheng Yu, Gautier M Courbon, Ana Paula Lobez Rodriguez, Chen-Yi Cheung, Yingke Liang, Claire E Coupland, Stephanie A Bueler, Gregory M Cook, Peter Brzezinski and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Dual inhibition of respiratory complexes inMicrobiology spectrum · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Capturing the native structure of membrane proteins using vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Antibiotics (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin M Di TraniMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-4764-4009
Jiacheng Yu *Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0009-0000-2588-0428
Gautier M Courbon *Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-6628-9087
Ana Paula Lobez Rodriguez *Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm SE-106 91, Sweden.
Chen-Yi Cheung *Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand.
Yingke LiangMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-6247-8294
Claire E CouplandMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-6041-7532
Stephanie A BuelerMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Gregory M CookDepartment of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0001-8349-1500
Peter BrzezinskiDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm SE-106 91, Sweden.ORCID 0000-0003-3860-4988
John L RubinsteinMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-0566-2209

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) PJT162186Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2019.0043Royal Society of New Zealand | Marsden Fund (Royal Society of New Zealand Marsden Fund) n/a
6 · The paper itself

Abstract

To investigate the structure of the mycobacterial oxidative phosphorylation machinery, we prepared inverted membrane vesicles from

Indexed as

Cell MembraneCitric Acid CycleCryoelectron MicroscopyMycobacterium smegmatisAerobiosisBacterial ProteinsElectron TransportElectron Transport Complex IIIBacterial ProteinsElectron Transport Complex IIIcryo-EMelectron transport chainmembrane vesiclesMqomycobacteria

Identifiers

PMID39969994
PMCPMC11874196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.