Evidence map›Paper›PMID 39969966›Full record

ArticleMolecular biology of the cell2025

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast.

Catherine Tan, Michael C Lanz, Matthew Swaffer, Jan Skotheim, Fred Chang

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Catherine TanDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143.
Michael C LanzDepartment of Biology, Stanford University, Stanford, CA 94305.
Matthew SwafferDepartment of Biology, Stanford University, Stanford, CA 94305.
Jan SkotheimDepartment of Biology, Stanford University, Stanford, CA 94305.
Fred ChangDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0002-8907-3286

Funding

Determining how cell growth triggers cell divisionR35GM134858 · NIGMS · STANFORD UNIVERSITY · PI Jan M Skotheim · 2020 to 2026
$4.1M
Mechanics of cell growth and divisionR35GM141796 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Fred Chang · 2021 to 2026
$3.7M
NIGMS NIH HHS R35 GM134858NIGMS NIH HHS R35 GM141796Wellcome Trust
6 · The paper itself

Abstract

Diffusion in the cytoplasm can greatly impact cellular processes, yet regulation of macromolecular diffusion remains poorly understood. There is increasing evidence that cell size affects the density and macromolecular composition of the cytoplasm. Here, we studied whether cell size affects diffusion at the scale of macromolecules tens of microns in diameter. We analyzed the diffusive motions of intracellular genetically-encoded multimeric 40 nm nanoparticles (cytGEMs) in the cytoplasm of the fission yeast

Indexed as

CytoplasmSchizosaccharomycesCell SizeCytokinesisDiffusionHumansNanoparticlesProteomeSchizosaccharomyces pombe ProteinsProteomeSchizosaccharomyces pombe Proteins

Identifiers

PMID39969966
PMCPMC12005113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.