ArticleObesity surgery2025
Association of Preoperative Serum 25-Hydroxyvitamin D with Longitudinal Body Mass Index After Bariatric Surgery-A Mediation Effect of Serum Albumin.
Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe predictive ability of vitamin D for weight loss after bariatric surgery is not well-characterized. This prospective cohort study assessed the utility of preoperative serum 25-hydroxyvitamin D (25(OH)D) as a predictor of body mass index (BMI) at follow-up after bariatric surgery. Additionally, the mediation role of serum albumin was explored.
methodsPatients scheduled for bariatric surgery were recruited from a single center. The final analyzed cohort consisted of 316 subjects (age, 40 ± 10 years; 35.4% males; BMI, 42.6 ± 7.2 kg/m
resultsBefore surgery, 98.5% of patients had vitamin D insufficiency (25(OH)D < 30 μg/L). Baseline BMI elevated progressively as severity of vitamin D insufficiency increased (P-trend = 0.025). Lower 25(OH)D levels were independently associated with higher preoperative BMI (coefficient, - 0.20; 95% CI, - 0.32 to - 0.08; P = 0.001) or less BMI reduction at follow-up (coefficient, - 0.15; 95% CI, - 0.25 to - 0.04; P = 0.007), after adjustment for baseline demographics, diabetes status, and/or surgical procedure. The association diminished after accounting for albumin, which emerged as a significant determinant (coefficient, - 0.61; 95% CI, - 0.83 to - 0.40; P < 0.001). Mediation analysis showed that reduced albumin explained 30% (P < 0.001) of the relationship between 25(OH)D and longitudinal BMI.
conclusionsLower preoperative 25(OH)D is associated with less BMI reduction over 1-year follow-up after bariatric surgery, potentially mediated by reduced serum albumin.
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