Evidence map›Paper›PMID 39969768›Full record

ArticlePurinergic signalling2025

SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation.

Jin Peng, Xinyu Huang, Peijie Liu, Yushi Hu, Liang Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jin PengCollege of Sport Medicine and Health, Chengdu Sport University, Chengdu, 610041, China.
Xinyu HuangCollege of Sport Medicine and Health, Chengdu Sport University, Chengdu, 610041, China.
Peijie LiuCollege of Sport Medicine and Health, Chengdu Sport University, Chengdu, 610041, China.
Yushi HuCollege of Sport Medicine and Health, Chengdu Sport University, Chengdu, 610041, China.
Liang KangInstitute of Sport Medicine and Health, Chengdu Sport University, Chengdu, 610041, China. kangliang@cdsu.edu.cn.

Funding

Expert Centre Foundation of Sichuan Province A2020-SCZJJCB02Expert Centre Foundation of Sichuan Province A2020-SCZJZHC02National Natural Science Foundation of China 81704190National Natural Science Foundation of China 82074576Project of Chinese Medicine Administration Bureau of Sichuan Province 2021MS444
6 · The paper itself

Abstract

Adenosine, a sleep-associated neuromodulator, is crucial in various physiological and pathological processes. Previous studies have demonstrated that sleep deprivation (SD) alters striatal neuronal activity. In this study, we used in vitro electrophysiological recordings to investigate the effects of 20 h of SD on the neuronal excitability of mouse dorsal striatal medium spiny neurons (MSNs). Our findings revealed that SD resulted in altered action potential (AP) discharge properties and reduced neuronal excitability compared to the control group. Importantly, these changes were partially offset by the prophylactic injection of the A2A receptor (A2AR) antagonist SCH58261. Additionally, 20 h of SD caused a decrease in the amplitude and an increase in the interval of spontaneous excitatory postsynaptic currents (sEPSCs) compared to control. However, the prophylactic injection of the A2AR antagonism shortened the sEPSC interval, while the A1 receptor (A1R) antagonist DPCPX not only shortened the interval but also further reduced the amplitude of sEPSCs. Thus, it can be concluded that SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation, whereas DPCPX does not.

Indexed as

Adenosine A2 Receptor AntagonistsCorpus StriatumNeuronsPyrimidinesSleep DeprivationTriazolesAction PotentialsAnimalsExcitatory Postsynaptic PotentialsMaleMiceMice, Inbred C57BL5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidineAdenosine A2 Receptor AntagonistsPyrimidinesTriazolesAdenosineDPCPXElectrophysiologyMSNsSCH68261Sleep deprivation

Identifiers

PMID39969768
PMCPMC12454743

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.