Evidence map›Paper›PMID 39969753›Full record

ReviewDiscover oncology2025

The prognosis of ciRS-7 and circHIPK3 in pan-cancer: a mini-review and meta-analysis.

Xiangji Li, Tong Wu, Ruihan Dong, Xiaoying Wu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangji Li *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory for Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, People's Republic of China.
Tong Wu *Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Ruihan DongDepartment of Nursing, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People's Republic of China.
Xiaoying WuDepartment of Endocrinology, Peking University Fifth School of Clinical Medicine, Beijing Hospital, National Center of Gerontology, Beijing, 100005, People's Republic of China. 2211110755@stu.pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) are increasingly recognized for their potential as cancer biomarkers. Although various studies have investigated the biological function of ciRS-7 and circHIPK3 in malignant tumors, their prognostic value in pan-cancer has not been systematically analyzed.

methodsWe systematically searched the PubMed, Web of Science, and Cochrane Library databases from January 1, 1990, to October 14, 2024. The impact of ciRS-7 or circHIPK3 on prognostic outcomes, including overall survival (OS) and disease-free survival (DFS), was assessed by pooled hazard ratios (HR). The association between CiRS-7 or circHIPK3 and clinical features was evaluated using odds ratios (OR). The Data analysis was conducted using Review Manager 5.4.

resultsFor most cancers, our meta-analysis of 14 studies (N = 2140) and 15 studies (N = 1045) showed that high ciRS-7 and circHIPK3 were associated with worse OS. Pooled analysis of 5 studies (N = 421) and 2 studies (N = 248) indicated that high ciRS-7 and circHIPK3 were also associated with shorter DFS. Additionally, high ciRS-7 and circHIPK3 expression were associated with worse histological grade, higher TNM stage, larger tumor size, more lymph node and distant metastasis.

conclusionHigh ciRS-7 and circHIPK3 were significantly associated with poor prognosis and advanced clinical features in most cancers, suggesting their potential as prognostic biomarkers.

Indexed as

CircHIPK3CiRS-7Meta-analysisMolecular basisPrognosis

Identifiers

PMID39969753
PMCPMC11839969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.