Evidence map›Paper›PMID 39969750›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Cognitive and behavioral follow-up of patients with amyotrophic lateral sclerosis type 8.

Cássia de Alcântara, Marcelo Maroco Cruzeiro, Marcondes Cavalcante França, Mariana Asmar Alencar, Caroline Martins de Araújo, Sarah Teixeira Camargos, Leonardo Cruz de Souza

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cássia de AlcântaraPrograma de Pós-Graduação em Neurociências da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-3444-5628
Marcelo Maroco CruzeiroDepartamento de Clínica Médica, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.ORCID http://orcid.org/0000-0001-6898-2790
Marcondes Cavalcante FrançaDepartamento de Neurologia, Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0898-2419
Mariana Asmar AlencarDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-3881-5283
Caroline Martins de AraújoPrograma de Pós-Graduação em Neurociências da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-8866-0374
Sarah Teixeira CamargosPrograma de Pós-Graduação em Neurociências da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-9829-6783
Leonardo Cruz de SouzaPrograma de Pós-Graduação em Neurociências da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. leocruzsouza@ufmg.br.ORCID http://orcid.org/0000-0001-5027-9722

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Bolsa de ProdutividadeFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02980-17
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAmyotrophic Lateral Sclerosis type 8 (ALS8) is a familial motor neuron disease caused by the VAPB p.P56S mutation. There is a lack of longitudinal studies to elucidate the cognitive and behavioral progression of this disease. We aimed to investigate the progression of cognitive performance and behavioral symptoms of ALS8 patients over time.

methodsThe cohort was composed of 23 ALS8 patients (12 men). They underwent neuropsychological assessments in two periods of time, ranging from 24 to 48 months (mean follow-up: 33 ± 10).

resultsThere was mild motor and functional decline during the follow-up. There were no significant differences between the first and the second evaluation on tests of verbal fluency, executive functions, episodic memory, and facial emotion recognition. There was a decline in the Language subdomain from the Addenbrooke's Cognitive Examination-revised. Behavioural measures indicated decreasing stereotypic behaviours. Anxiety and depression symptoms remained stable. No patient developed dementia.

conclusionCognitive decline parallels motor degeneration in ALS8, with a slow pattern of progression.

Indexed as

Amyotrophic Lateral SclerosisCognitive DysfunctionAdultAgedDisease ProgressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsAmyotrophic lateral sclerosisBehaviorCognitionDementiaVAPB

Identifiers

PMID39969750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.