Evidence map›Paper›PMID 39969640›Full record

ArticleMaternal and child health journal2025

The Association Between Longer Maternal Leukocyte Telomere Length in the Immediate Postpartum Period and Preterm Birth in a Predominately Latina Cohort of Mothers.

Usah Dutson, Jue Lin, Laura L Jelliffe-Pawlowski, Kimberly Coleman-Phox, Larry Rand, Janet M Wojcicki

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Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Observational
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Usah DutsonDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Francisco, UCSF Benioff Children's Hospital, 550 16th Street, 5th Floor, Mail Code 0136, San Francisco, CA, 94158, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Laura L Jelliffe-PawlowskiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Kimberly Coleman-PhoxCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Larry RandCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
Janet M WojcickiDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Francisco, UCSF Benioff Children's Hospital, 550 16th Street, 5th Floor, Mail Code 0136, San Francisco, CA, 94158, USA. Janet.Wojcicki@ucsf.edu.ORCID http://orcid.org/0000-0002-3393-1368

Funding

UCSF Preterm Birth Initiative Wojcicki
6 · The paper itself

Abstract

objectivesWe investigated the association between maternal leukocyte telomere length (LTL) in the immediate postpartum period and moderate to late preterm birth (32- < 37 weeks) among Latinas, a population at high risk for preterm birth.

methodsMaternal LTL was measured using quantitative polymerase chain reaction at delivery in a prospective San Francisco primarily Latina birth cohort. Logistic regression models were used to investigate the association between postpartum maternal LTL and preterm birth. Maternal LTL was analyzed as a continuous predictor.

resultsOut of 194 participants, 23 (11.9%) had preterm delivery. Longer postnatal maternal LTL was associated with preterm birth (crude OR 4.68; 95% confidence interval (CI) 1.07, 20.6, p = 0.039; adjusted OR 12.8, 95% CI 1.83, 99.9, p = 0.010). Age-stratified analysis showed that being under 35 years increased the effect size of the association between maternal LTL and preterm birth (adjusted OR 32.5, 95% CI 2.58, 597, p < 0.01). CONCLUSIONS FOR PRACTICE: Latina mothers with moderate to late preterm infants had longer LTL in the immediate postpartum period compared to those with term infants. This association was stronger for mothers under the age of 35 years. LTL may serve as a biomarker to better understand the pathophysiology and risk of preterm birth and could inform targeted interventions for prevention and early detection. Future studies are needed to understand physiological changes in maternal LTL from the prenatal to postnatal period in relation to birth outcomes.

Indexed as

Hispanic or LatinoLeukocytesMothersPostpartum PeriodPremature BirthTelomereAdultCohort StudiesFemaleHumansInfant, NewbornPregnancyProspective StudiesRisk FactorsSan FranciscoHispanicLatinaLatinxLeukocyte telomere lengthMaternal telomere lengthPreterm

Identifiers

PMID39969640
PMCPMC11926058

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